The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008].
Zhou, Cao, Yang, Cong, Wang, Chen, Yin, Wu, Cai, Liu, Xiao: "Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulation of RSK2 protein signaling." in: The Journal of biological chemistry, Vol. 288, Issue 9, pp. 6259-71, (2013) (PubMed).
Nakrieko, Vespa, Mason, Irvine, DSouza, Dagnino: "Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 14, pp. 2157-66, (2008) (PubMed).
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).
Kumar, Naruszewicz, Wang, Leung-Hagesteijn, Hannigan: "ILKAP regulates ILK signaling and inhibits anchorage-independent growth." in: Oncogene, Vol. 23, Issue 19, pp. 3454-61, (2004) (PubMed).