anti-CLOCK (CLOCK) 抗体产品概述

Full name:
anti-Clock Homolog (Mouse) 抗体 (CLOCK)
在www.antibodies-online.cn可供118 Clock Homolog (Mouse) (CLOCK) 抗体的23不同的供货商。 再加上,我们可以发CLOCK 试剂盒 (7)CLOCK 蛋白 (5)和数多这个蛋白质的别的产品。 总共138 CLOCK产品已列进来了。
5330400M04Rik, bHLHe8, bHLHe10, CG7391, clk, clock, dClck, dclk, dCLK/JRK, dClock, Dmel\\CG7391, Jerk, jrk, KAT13D, mKIAA0334, PAS1, Xclk, XClock, zCLOCK1, zfCLOCK1

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引用最多的anti-CLOCK 抗体

  1. Human Polyclonal CLOCK Primary Antibody for ChIP, WB - ABIN151057 : Jin, Shearman, Weaver, Zylka, de Vries, Reppert: A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. in Cell 1999 (PubMed)
    Show all 6 references for 151057

  2. Human Polyclonal CLOCK Primary Antibody for EIA, IHC (p) - ABIN359753 : Marino, Holt, Chen, Davis: Shift work, hCLOCK T3111C polymorphism, and endometriosis risk. in Epidemiology (Cambridge, Mass.) 2008 (PubMed)
    Show all 3 references for 359753

  3. Human Monoclonal CLOCK Primary Antibody for ICC, ELISA - ABIN969059 : Lee, Paik, Kang, Lim, Kim: Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference. in Chronobiology international 2007 (PubMed)
    Show all 2 references for 969059

  4. Human Polyclonal CLOCK Primary Antibody for IHC, ELISA - ABIN1533501 : Steeves, King, Zhao, Sangoram, Du, Bowcock, Moore, Takahashi: Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei. in Genomics 1999 (PubMed)

  5. Human Polyclonal CLOCK Primary Antibody for ELISA, WB - ABIN564129 : Kalamvoki, Roizman: Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)


Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC (显示 COX6C 抗体) E-box binding, thus enhancing the removal of CLK-CYC (显示 COX6C 抗体) from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC (显示 COX6C 抗体) from E-boxes

  2. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  3. Our findings suggest a novel role for clock protein (显示 ARNTL 抗体) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  4. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  5. Computational dissection of CLK/CYC (显示 COX6C 抗体) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  6. usp8 (显示 USP8 抗体) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (显示 USP8 抗体)-DN) enhances CLK/CYC (显示 COX6C 抗体) transcriptional activity and alters fly locomotor activity rhythms

  7. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  8. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  9. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  10. findings show that Clk and cyc (显示 COX6C 抗体) act during starvation to modulate the conflict of whether flies sleep or search for food

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Data suggest that Clock1a coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 (显示 SMAD3 抗体) signaling; Clock1a alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a activates Smad3a (显示 SMAD3 抗体) promoter via its E-box1 element. (Clock1a = clock circadian regulator a; Nodal = nodal modulator 1 (显示 NOMO1 抗体); Smad3a (显示 SMAD3 抗体) = SMAD (显示 SMAD1 抗体) family member 3a)

  2. effect of CRY (显示 CRY2 抗体) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Clock protein (显示 ARNTL 抗体) role in proteasomal and autophagic BMAL1 (显示 ARNTL 抗体) degradation and glucose homeostasis

  2. CLOCK transcription control of Wnt (显示 WNT2 抗体) signaling promotes cell cycle progression in 3T3-L1 preadipocytes.

  3. results demonstrate that the core circadian gene Clock regulates bone formation via transcriptional control of 1,2,5(OH)2D3 receptor PDIA3 (显示 PDIA3 抗体)

  4. These results suggest that bone resorption and bone mass are regulated at a sophisticated level by osteoblastic Clock system through a mechanism relevant to the modulation of 1,25(OH)2 D3 -induced Rankl (显示 TNFSF11 抗体) expression in osteoblasts.

  5. Abundance of CDH1 (显示 CDH1 抗体) and TP63 (显示 TP63 抗体) proteins were significantly reduced in cultures transfected with shClock These data support how CLOCK plays a role in regulation of epithelial cell growth and differentiation in the mammary gland.

  6. Data demonstrate that CLOCK and BMAL1 (显示 ARNTL 抗体) regulate muscle insulin (显示 INS 抗体) sensitivity via SIRT1 (显示 SIRT1 抗体), and activation of SIRT1 (显示 SIRT1 抗体) might be a potential valuable strategy to attenuate muscle insulin (显示 INS 抗体) resistance related to circadian misalignment.

  7. These data establish the importance of circadian CLOCK-inhibin signaling in sepsis.

  8. our results indicate that Clock is a key regulator of AKT (显示 AKT1 抗体) signalling for triggering cardiac hypertrophy in vivo.

  9. Report altered BMAL1 (显示 ARNTL 抗体)/CLOCK expression in conditions of chronically altered blood flow.

  10. PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp (显示 GC 抗体) gene by targeting BMAL1 (显示 ARNTL 抗体) and CLOCK.

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. found that overexpression of both Clock and Bmal1 (显示 ARNTL 抗体) suppressed cell growth

  2. Clock circadian regulator (CLOCK) gene single nucleotide polymorphism rs1801260 minor allele C showed a significantly higher association with the prevalence of diabetes in the Japanese population independent of body mass index (BMI).

  3. Immunostaining of CLOCK and PER2 (显示 PER2 抗体) protein was detected in the granulosa cells of dominant antral follicles but was absent in the primordial, primary, or preantral follicles of human ovaries.Oscillating expression of the circadian gene PER2 (显示 PER2 抗体) can be induced by testosterone in human granulosa cells in vitro. Expression of STAR also displayed an oscillating pattern after testosterone stimulation

  4. possible circadian rhythm in full-term placental expression

  5. Findings indicate that CLOCK protein (显示 ARNTL 抗体) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  6. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  7. when overexpressed, c-MYC (显示 MYC 抗体) is able to repress Per1 (显示 PER1 抗体) transactivation by BMAL1 (显示 ARNTL 抗体)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (显示 MYC 抗体) was detected in BMAL1 (显示 ARNTL 抗体) protein complexes

  8. CLOCK, ARNTL (显示 ARNTL 抗体), and NPAS2 (显示 NPAS2 抗体) gene polymorphisms may have a role in seasonal variations in mood and behavior

  9. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

  10. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 (显示 ARNTL 抗体) by CBP (显示 CREBBP 抗体) for immediate-early (显示 JUN 抗体) Per induction and the resetting of the circadian clock.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (显示 CRY2 抗体) is important for repression through facilitating interaction with CLOCK

CLOCK 抗原简介

Antigen Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with CLOCK

  • Clock (Clk) 抗体
  • clock homolog (mouse) (CLOCK) 抗体
  • clock circadian regulator (clock) 抗体
  • clock homolog (CLOCK) 抗体
  • clock (clock) 抗体
  • circadian locomotor output cycles kaput (Clock) 抗体
  • clock circadian regulator (Clock) 抗体
  • clock circadian regulator (CLOCK) 抗体
  • 5330400M04Rik 抗体
  • bHLHe8 抗体
  • bHLHe10 抗体
  • CG7391 抗体
  • clk 抗体
  • clock 抗体
  • dClck 抗体
  • dclk 抗体
  • dCLK/JRK 抗体
  • dClock 抗体
  • Dmel\\CG7391 抗体
  • Jerk 抗体
  • jrk 抗体
  • KAT13D 抗体
  • mKIAA0334 抗体
  • PAS1 抗体
  • Xclk 抗体
  • XClock 抗体
  • zCLOCK1 抗体
  • zfCLOCK1 抗体

Protein level used designations for CLOCK

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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