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Interleukin 18 Binding Protein (IL18BP) (AA 31-194) (Active) protein (His tag)

ABIN2181348 产品详细信息, 供应商: Log in to see
蛋白名称
  • IL18BP
  • IL-18BP
  • Igifbp
  • MC54L
  • IL18BPa
  • interleukin 18 binding protein
  • IL18BP
  • LOC100340371
  • Il18bp
产品特性
AA 31-194
8
3
2
2
1
1
1
宿主

17
6
2
资源
HEK-293 Cells
11
3
3
2
2
1
1
1
1
蛋白类型
Recombinant
生物活性
Active
标记
This IL18BP protein is labelled with His tag.
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产品特性 This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.5 kDa. The protein migrates as 28-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
纯度 >95 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
背景 Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
分子量 18.5 kDa
NCBI登录号 NP_001138529
UniProt O95998
研究领域 Cytokines, Immunology, Virology, Inflammation, Cancer
限制 仅限研究用
状态 Lyophilized
溶解方式 Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for Interleukin 18 Binding Protein (IL18BP) (AA 31-194) (Active) protein (His tag) (ABIN2181348) Interleukin 18 Binding Protein (IL18BP) (AA 31-194) (Active) protein (His tag)
背景 Novick, Kim, Fantuzzi, Reznikov, Dinarello, Rubinstein: "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response." in: Immunity, Vol. 10, Issue 1, pp. 127-36, 1999 (PubMed).

Aizawa, Akita, Taniai, Torigoe, Mori, Nishida, Ushio, Nukada, Tanimoto, Ikegami, Ikeda, Kurimoto: "Cloning and expression of interleukin-18 binding protein." in: FEBS letters, Vol. 445, Issue 2-3, pp. 338-42, 1999 (PubMed).