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抗Human Cyclin A 抗体:
抗Mouse (Murine) Cyclin A 抗体:
抗Rat (Rattus) Cyclin A 抗体:
Cow (Bovine) Monoclonal Cyclin A Primary Antibody for ICC, WB - ABIN3043070
Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ... in European journal of medicinal chemistry 2014
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Human Polyclonal Cyclin A Primary Antibody for ICC, IF - ABIN441337
Pan, Nakade, Huang, Zhu, Masuzaki, Hasegawa, Murata, Yoshiki, Yamaguchi, Lee, Yang, Tsai, Obata, Yokoyama: Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. in Oncogene 2010
Show all 2 Pubmed References
Human Polyclonal Cyclin A Primary Antibody for ChIP, ICC - ABIN4301457
Mazurek, Luo, Krasnitz, Hicks, Powers, Stillman: DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. in Cancer discovery 2012
Human Polyclonal Cyclin A Primary Antibody for IF (p), IHC (p) - ABIN670281
Zhang, Pan, Xu, Niu, Ma, Xu: Interleukin 18 augments growth ability via NF-?B and p38/ATF2 pathways by targeting cyclin B1, cyclin B2, cyclin A2, and Bcl-2 in BRL-3A rat liver cells. in Gene 2015
Low CCNA expression is associated with lung cancer progression.
cyclin D1 (显示 CCND1 抗体) and other cyclins such as cyclin A regulates DNA integrity through RAD51 (显示 RAD51 抗体) interaction with the BRCA2 (显示 BRCA2 抗体) C-terminal domain
inhibition of PDK4 (显示 PDK4 抗体) activity in Hepatocellular carcinoma cells increased cyclin E1 (显示 CCNE1 抗体), cyclin A2, and E2F1 (显示 E2F1 抗体) proteins.
An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (显示 CDK2 抗体) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (显示 WEE1 抗体) inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (显示 CDKN1A 抗体), p27 (显示 PAK2 抗体)-cyclin E (显示 CCNE1 抗体),A/Cdk2 (显示 CDK2 抗体) pathway.
On analyzing cyclin A and B1 (CCNA and CCNB1 (显示 CCNB1 抗体)) expression, positive staining in 90% cases of PTC (显示 F9 抗体) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (显示 F9 抗体).
Study describes a positive feedback loop centred on cyclin A2-Cdk2 (显示 CDK2 抗体) inhibition of interphase APC (显示 APC 抗体)/C-Cdc20 (显示 CDC20 抗体) to allow further cyclin A2 accumulation and mitotic entry.
PIWIL2 (显示 PIWIL2 抗体) has a role in promoting progression of non-small cell lung cancer by inducing CDK2 (显示 CDK2 抗体) and Cyclin A expression
Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the human cytomegalovirus (HCMV) replication cycle.
We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.
Cyclin A2 binds to Mre11 (显示 MRE11A 抗体) mRNA to promote Mre11 (显示 MRE11A 抗体) translation and repair of replication errors.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Meioc-deficient spermatocytes that have initiated synapsis mis (显示 AMH 抗体)-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
cyclin A2 controlled Mre11 (显示 MRE11A 抗体) abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 (显示 MRE11A 抗体) transcripts to mediate polysome loading and translation.
hese data suggest that mmu-miR (显示 MLXIP 抗体)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (显示 EEF2K 抗体) and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (显示 CTNNB1 抗体) and phospholipase C (显示 PLC 抗体) pathways.
Ccn2 (显示 CTGF 抗体) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
B-Myb (显示 MYBL2 抗体) represses SMC (显示 DYM 抗体) elastin (显示 ELN 抗体) gene expression and cyclin A plays a role in the developmental regulation of elastin (显示 ELN 抗体) gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
an essential role for UHRF1 (显示 UHRF1 抗体) phosphorylation by cyclin-dependent kinase 2 (显示 CDK2 抗体)/cyclin A2 during early vertebrate development
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, cyclin A2
, Cyclin A2 (Cyclin A)