anti-CDKN1A (CDKN1A) 抗体产品概述

Full name:
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) 抗体 (CDKN1A)
在www.antibodies-online.cn可供581 Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) 抗体的24不同的供货商。 再加上,我们可以发CDKN1A 试剂盒 (24)CDKN1A 蛋白 (16)和数多这个蛋白质的别的产品。 总共658 CDKN1A产品已列进来了。
别名:
CAP20, CCND1, CDKI, Cdkn1, CDKN1A, CIP1, MDA-6, mda6, p16Xic2, P21, p21Cip1, p21WAF, SDI1, si:ch1073-48m5.2, UV96, WAF1
列出全部抗体 基因 基因ID UniProt
CDKN1A 114851  
CDKN1A 1026 P38936
CDKN1A 12575 P39689

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引用最多的anti-CDKN1A 抗体

  1. Human Polyclonal CDKN1A Primary Antibody for FACS, IF - ABIN391763 : Fukuchi, Nakamura, Ichimura, Tatsumi, Gomi: The association of cyclin A and cyclin kinase inhibitor p21 in response to gamma-irradiation requires the CDK2 binding region, but not the Cy motif. in Biochimica et biophysica acta 2003 (PubMed)
    Show all 5 references for 391763

  2. Human Polyclonal CDKN1A Primary Antibody for DB, EIA - ABIN358179 : Scott, Kimura, Dong, Ichinohasama, Bergen, Kerviche, Sheridan, DeCoteau: Methylation status of cyclin-dependent kinase inhibitor genes within the transforming growth factor beta pathway in human T-cell lymphoblastic lymphoma/leukemia. in Leukemia research 2004 (PubMed)
    Show all 5 references for 358179

  3. Human Polyclonal CDKN1A Primary Antibody for EIA, IHC (p) - ABIN358182 : Amini, Saunders, Kelley, Khalili, Sawaya: Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358182

  4. Human Polyclonal CDKN1A Primary Antibody for EIA, IHC (p) - ABIN359673 : Frouin, Maga, Denegri, Riva, Savio, Spadari, Prosperi, Scovassi: Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for 359673

  5. Human Polyclonal CDKN1A Primary Antibody for IF, WB - ABIN653259 : Chen, Turner, McCarthy, Scaltriti, Bettuzzi, Yeatman: Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent. in Cancer research 2004 (PubMed)
    Show all 3 references for 653259

  6. Human Polyclonal CDKN1A Primary Antibody for WB - ABIN655723 : Noma, Kirino, Ikeuchi, Suzuki: Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. in The EMBO journal 2006 (PubMed)
    Show all 2 references for 655723

  7. Human Monoclonal CDKN1A Primary Antibody for FACS, IHC (p) - ABIN180466 : Buckley, Sweeney, Hamilton, Sini, Manning, Nicholson, deFazio, Watts, Musgrove, Sutherland: Expression and amplification of cyclin genes in human breast cancer. in Oncogene 1993 (PubMed)
    Show all 2 references for 180466

  8. Human Polyclonal CDKN1A Primary Antibody for IF, IHC (p) - ABIN657391 : Hu, Gartenhaus, Eichberg, Liu, Fang, Rapoport: PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21. in Oncogene 2010 (PubMed)

  9. Human Polyclonal CDKN1A Primary Antibody for EIA, IHC (p) - ABIN358181 : Marqués, Kumar, Poveda, Zuluaga, Hernández, Jackson, Pasero, Carrera: Specific function of phosphoinositide 3-kinase beta in the control of DNA replication. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)

更多抗CDKN1A的相互作用对抗体

Zebrafish Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a

  2. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (显示 CDK1 抗体), wee1 (显示 WEE1 抗体), p21, PCNA (显示 PCNA 抗体) and cdk2 (显示 CDK2 抗体), but only weakly influences cyclin B1 (显示 CCNB1 抗体), cyclin B2 (显示 CCNB2 抗体) and cyclin E1 (显示 CCNE1 抗体) expression.

Human Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. SUMO and p21Cip1 regulate the transit of proteins through the nucleolus; disruption of nucleolar export by DNA damage induces SUMO and p21Cip1 to act as hub proteins to form a multiprotein complex in the nucleolus.

  2. HULC activates p53 (显示 TP53 抗体)-p21 pathway and promotes nasopharyngeal carcinoma cell growth.

  3. We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a

  4. miRNAs miR (显示 MLXIP 抗体)-106b and miR (显示 MLXIP 抗体)-20a that target p21 were specifically downregulated in HIV-1 infected CD4 (显示 CD4 抗体)+ T cells.

  5. Increased nuclear localization of p21(WAF1/CIP1) in SPRY2 (显示 SPRY2 抗体) downregulated colon cancer cells may explain the inhibition of cell proliferation in colon cancer cells.

  6. This article discusses the controversial aspects of the two-faced involvement of p21 in cancer and speculate on how this new information may increase our understanding of its role in cancer pathogenesis. Prevailing notions indicate that p21 might also act as antiapoptotic agent, which may have relevant implications for future therapeutic strategies. [review]

  7. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (显示 F2 抗体)-activatable receptor PAR-1 (protease-activated receptor-1 (显示 F2R 抗体)), in Runx1 (显示 RUNX1 抗体)/Cbfb (显示 CBFB 抗体)-deleted MLL (显示 MLL 抗体)-AF9 (显示 MLLT3 抗体) cells. Similar to the effect of Runx1 (显示 RUNX1 抗体)/Cbfb (显示 CBFB 抗体) deletion, PAR-1 (显示 MARK2 抗体) overexpression induced CDKN1A/p21 expression and attenuated proliferation in MLL (显示 MLL 抗体)-AF9 (显示 MLLT3 抗体) cells

  8. Results provide evidence that Foxp3 (显示 FOXP3 抗体) is a downstream target of p53 (显示 TP53 抗体) and that is sufficient to induce p21 expression, ROS (显示 ROS1 抗体) production and p53 (显示 TP53 抗体)-mediated senescence.

  9. both in vitro and in vivo studies proved that CypD (显示 CYPD 抗体) inhibitor-based treatment was able to efficiently impair this interaction, leading to a tumor formation reduction. All together, these findings indicate that the countering effect of CypD (显示 CYPD 抗体) on the p53 (显示 TP53 抗体)-p21 pathway participates in oncogene (显示 RAB1A 抗体)-dependent transformation.

  10. The deletion of CBX3 (显示 CBX3 抗体) directly enforces the expression of CDK6 (显示 CDK6 抗体) and p21.

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) interaction partners

  1. Data show that Emu-Myc (显示 MYC 抗体) mice lacking both p21 (显示 D4S234E 抗体) and PUMA (显示 BBC3 抗体) developed lymphoma at a rate considerably longer latency than Emu-Myc (显示 MYC 抗体);p53 (显示 TP53 抗体)(+/-)mice.

  2. Study reports that p27 (显示 CDKN1B 抗体) normally exerts a negative feedback on p21 (显示 D4S234E 抗体) expression: p27 (显示 CDKN1B 抗体) directly represses the expression of the transcription factor Pitx2 (显示 PITX2 抗体) which in turn maintains decreased p21 (显示 D4S234E 抗体) levels. Consequently, in cells lacking p27 (显示 CDKN1B 抗体), de-repression of Pitx2 (显示 PITX2 抗体) causes the up-regulation of p21 (显示 D4S234E 抗体) showing a new mechanism by which p27 (显示 CDKN1B 抗体) regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (显示 PITX2 抗体) and p21 (显示 D4S234E 抗体).

  3. p21 (显示 D4S234E 抗体)-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 (显示 D4S234E 抗体) and ras(Ha)/ROCK2 (显示 ROCK2 抗体)/NF-kappaB (显示 NFKB1 抗体) signalling in skin carcinogenesis.these data show that ROCK2 (显示 ROCK2 抗体) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (显示 TP53 抗体) loss and novel NF-kappaB (显示 NFKB1 抗体) expression

  4. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (显示 F2 抗体)-activatable receptor PAR-1 (protease-activated receptor-1 (显示 F2R 抗体)), in Runx1 (显示 RUNX1 抗体)/Cbfb (显示 CBFB 抗体)-deleted MLL (显示 MLL 抗体)-AF9 (显示 MLLT3 抗体) cells. Similar to the effect of Runx1 (显示 RUNX1 抗体)/Cbfb (显示 CBFB 抗体) deletion, PAR-1 (显示 MARK2 抗体) overexpression induced CDKN1A/p21 expression and attenuated proliferation in MLL (显示 MLL 抗体)-AF9 (显示 MLLT3 抗体) cells

  5. both in vitro and in vivo studies proved that CypD (显示 CYPD 抗体) inhibitor-based treatment was able to efficiently impair this interaction, leading to a tumor formation reduction. All together, these findings indicate that the countering effect of CypD (显示 CYPD 抗体) on the p53 (显示 TP53 抗体)-p21 (显示 D4S234E 抗体) pathway participates in oncogene (显示 RAB1A 抗体)-dependent transformation.

  6. FLT3 (显示 FLT3 抗体)-ITD is capable of inhibiting FLT3 (显示 FLT3 抗体)-ITD+ cell proliferation through the p21 (显示 D4S234E 抗体)/Pbx1 (显示 PBX1 抗体) axis

  7. These data reveal a novel role for p21/waf1 in the resolution of inflammation via its ability to control neutrophil apoptosis.

  8. the silencing of Cyclin-dependent kinase 5 (显示 CDK5 抗体) preventing memory dysfunction

  9. Results show that p21 (显示 D4S234E 抗体) expression is regulated by OLA1 (显示 OLA1 抗体) to promote cell proliferation and organogenesis.

  10. AS160 (显示 TBC1D4 抗体) regulates glucose-independent eukaryotic cell proliferation through p21 (显示 D4S234E 抗体)-dependent control of the cell cycle.

CDKN1A 抗原简介

Antigen Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Alternative names and synonyms associated with CDKN1A

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (cdkn1a) 抗体
  • cyclin-dependent kinase inhibitor 1 (cki1) 抗体
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A) 抗体
  • cyclin-dependent kinase inhibitor 1A (cdkn1a) 抗体
  • cyclin-dependent kinase inhibitor 1A (LOC100348489) 抗体
  • cyclin-dependent kinase inhibitor 1A (Cdkn1a) 抗体
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (Cdkn1a) 抗体
  • cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a) 抗体
  • CAP20 抗体
  • CCND1 抗体
  • CDKI 抗体
  • Cdkn1 抗体
  • CDKN1A 抗体
  • CIP1 抗体
  • MDA-6 抗体
  • mda6 抗体
  • p16Xic2 抗体
  • P21 抗体
  • p21Cip1 抗体
  • p21WAF 抗体
  • SDI1 抗体
  • si:ch1073-48m5.2 抗体
  • UV96 抗体
  • WAF1 抗体

Protein level used designations for CDKN1A

cyclin dependent kinase inhibitor p16Xic2 , cyclin-dependent kinase inhibitor 1 , cyclin D1 , cyclin-dependent kinase inhibitor 1A (p21, Cip1) , cip1 , p21 , waf1 , cyclin-dependent kinase inhibitor 1A , cyclin-dependent kinase inhibitor 1A (P21) , CDK-interacting protein 1 , CDK-interaction protein 1 , DNA synthesis inhibitor , melanoma differentiation associated protein 6 , wild-type p53-activated fragment 1 , p21/WAF1 , melanoma differentiation-associated protein , p21

GENE ID SPECIES
492305 Xenopus laevis
606440 Zea mays
747442 Pan troglodytes
100038054 Xenopus (Silurana) tropicalis
100302083 Ovis aries
100151416 Danio rerio
100348489 Oryctolagus cuniculus
114851 Rattus norvegicus
1026 Homo sapiens
474890 Canis lupus familiaris
513497 Bos taurus
100152215 Sus scrofa
100720449 Cavia porcellus
493943 Felis catus
12575 Mus musculus
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