anti-SIRT1 (SIRT1) 抗体产品概述

Full name:
anti-Sirtuin 1 抗体 (SIRT1)
在www.antibodies-online.cn可供329 Sirtuin 1 (SIRT1) 抗体的37不同的供货商。 再加上,我们可以发SIRT1 试剂盒 (44)SIRT1 蛋白 (18)和数多这个蛋白质的别的产品。 总共398 SIRT1产品已列进来了。
AA673258, SIR2, Sir2a, Sir2alpha, sir2l1, sirtuin, sirtuin 1
列出全部抗体 基因 基因ID UniProt
SIRT1 93759 Q923E4
SIRT1 23411 Q96EB6
SIRT1 309757  



所有可销售的anti-SIRT1 抗体


引用最多的anti-SIRT1 抗体

  1. Cow (Bovine) Polyclonal SIRT1 Primary Antibody for WB - ABIN2779607 : Solomon, Pasupuleti, Xu, McDonagh, Curtis, DiStefano, Huber: Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. in Molecular and cellular biology 2005 (PubMed)
    Show all 6 references for 2779607

  2. Human Monoclonal SIRT1 Primary Antibody for WB - ABIN1882053 : Vaziri, Dessain, Ng Eaton, Imai, Frye, Pandita, Guarente, Weinberg: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. in Cell 2001 (PubMed)
    Show all 5 references for 1882053

  3. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN729853 : Mohan, Kumar, Lackner, Alvarez: Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. in Journal of immunology (Baltimore, Md. : 1950) 2014 (PubMed)
    Show all 3 references for 729853

  4. Human Monoclonal SIRT1 Primary Antibody for ICC, FACS - ABIN969396 : Xie, Park, Kim, Hwang, Oh, Park, Shong, Lee, Choi: Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for 969396

  5. Human Monoclonal SIRT1 Primary Antibody for ICC, IF - ABIN2668278 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)
    Show all 2 references for 2668278

  6. Human Polyclonal SIRT1 Primary Antibody for IF (p), IHC (p) - ABIN745658 : Suzuki, Bartlett: Sirtuin1 and autophagy protect cells from fluoride-induced cell stress. in Biochimica et biophysica acta 2014 (PubMed)
    Show all 2 references for 745658

  7. Mouse (Murine) Polyclonal SIRT1 Primary Antibody for ELISA, WB - ABIN185702 : Chen, Steele, Lindquist, Guarente: Increase in activity during calorie restriction requires Sirt1. in Science (New York, N.Y.) 2005 (PubMed)
    Show all 2 references for 185702

  8. Human Monoclonal SIRT1 Primary Antibody for ELISA, FACS - ABIN4353901 : Lo Iacono, Visco-Comandini, Valzania, Viscomi, Coviello, Giampà, Roscini, Bisicchia, Siracusano, Troisi, Puglisi-Allegra, Carola: Adversity in childhood and depression: linked through SIRT1. in Translational psychiatry 2015 (PubMed)


Rabbit Sirtuin 1 (SIRT1) interaction partners

  1. Our findings revealed a novel regulatory mechanism of innate immunity by SIRT1.

  2. SIRT1 signaling pathway may be targeted for therapeutic intervention in flexor tendon injury.

Mouse (Murine) Sirtuin 1 (SIRT1) interaction partners

  1. Obesity-linked phosphorylation of SIRT1 inhibits its function and promotes pathological symptoms of nonalcoholic fatty liver disease. Ser-164 was identified as a major serine phosphorylation site in SIRT1 in obese, but not lean, mice, and this phosphorylation was catalyzed by casein kinase 2.

  2. SIRT1 promotes early-onset AHL (显示 CDH23 抗体) through suppressing FOXO3a (显示 FOXO3 抗体)-mediated oxidative stress resistance in the cochlea of C57BL/6 mice.

  3. In analyses of intestinal tissues, colitis induction, and gut (显示 GUSB 抗体) microbiota in mice with intestinal epithelial disruption of SIRT1, we found this protein to prevent intestinal inflammation by regulating the gut (显示 GUSB 抗体) microbiota.

  4. this study shows that SIRT1-dependent differentiation of Th9 cells confers protection against tumors and contributes to allergic airway inflammation

  5. SIRT1 interacts with and promotes the transactivation potential of RUNX2 (显示 RUNX2 抗体).

  6. Sirt1 might be directly involved in spermiogenesis in germ cells but not in steroidogenic cells. Germ cell-specific Sirt1 knockout mice were almost completely infertile; the early mitotic and meiotic progression of germ cells in spermatogenesis were not obviously affected after Sirt1 depletion, but subsequent spermiogenesis was disrupted by a defect in acrosome biogenesis.

  7. Sirt1 significantly reduced the levels of raptor (显示 RPTOR 抗体) and inactivated mammalian target of rapamycin (mTOR (显示 FRAP1 抗体))C1 signal by interacting with Akt2 (显示 AKT2 抗体).

  8. These findings indicate that SIRT1 is a key regulator of macrophage self-renewal that integrates cell cycle and longevity pathways.

  9. Sirt1 deacetylates p65 (显示 NFkBP65 抗体) and compromises NF-kappaB (显示 NFKB1 抗体) activity in hepatocytes.

  10. the roles of CTSB (显示 CTSB 抗体)/S and SIRT1 in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.

Human Sirtuin 1 (SIRT1) interaction partners

  1. Phosphorylated S164-SIRT1 and Casein Kinase 2 levels were also highly elevated in liver samples of nonalcoholic fatty liver disease patients and correlated with disease severity.

  2. Our data suggest that the p53 (显示 TP53 抗体)-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-adrenergic receptor (显示 ADRB2 抗体) signaling

  3. Up-regulation of transcription factor DeltaNp63 led to the decline of miR (显示 MLXIP 抗体)-181a expression, resulting in an overexpression of the antiaging protein Sirt1, in CD4 (显示 CD4 抗体)(+) T cells from HCV-infected individuals. Either reconstituting miR (显示 MLXIP 抗体)-181a or silencing DeltaNp63 or Sirt1 expression in CD4 (显示 CD4 抗体)(+) T cells led to accelerated T cell senescence.

  4. data reveals that the pathway 'HULC/USP22 (显示 USP22 抗体)/Sirt1/ protective autophagy' attenuates the sensitivity of hepatocellular carcinoma cells to chemotherapeutic agents, suggesting that this pathway may be a novel target for developing sensitizing strategy to hepatocellular carcinoma chemotherapy

  5. SIRT1 plays a key role in the inflammatory response in aseptic loosening through NF-kappaB (显示 NFKB1 抗体) deacetylation .

  6. The tumor-associated NADH oxidase (tNOX (显示 ENOX2 抗体))-mediated modulation of the NAD+ concentration and SIRT1 are involved in oxaliplatin-induced apoptosis.

  7. Up-regulated SIRT1 expression may serve as a potential biomarker for predicting the progression of cervical squamous intraepithelial lesions to invasive squamous cell carcinoma.

  8. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F (显示 HNRNPF 抗体), SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys.

  9. 7-amino-4-methylcoumarin did not affect acetyllysine preference in a multiply acetylated substrate. In contrast, AMC significantly enhanced KDAC6 substrate affinity, greatly reduced Sirt1 activity, eliminated the substrate sequence specificity of KDAC4, and had no consistent effect with KDAC8 substrates.

  10. SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via VDR (显示 CYP27B1 抗体) deacetylation.

Pig (Porcine) Sirtuin 1 (SIRT1) interaction partners

  1. Combining the in vivo and in vitro results, the effect of SIRT1 in granulosa cells apoptosis during follicular atresia was identified.

  2. SIRT1, p53 (显示 TP53 抗体) and NF-kappaB (显示 NFKB1 抗体) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. the expression of SIRT1 is associated with the Mt number in oocytes

  4. Resveratrol activated sirtuin 1 (Sirt1) gene expression and increased adipose triglyceride lipase (ATGL (显示 PNPLA2 抗体)) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 regulation pattern for PPARgamma (显示 PPARG 抗体) to that of ATGL (显示 PNPLA2 抗体) in adipocytes.

  5. CDK5 (显示 CDK5 抗体)-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.

  6. SIRT1 and LKB1 (显示 STK11 抗体)/AMPK (显示 PRKAA1 抗体) are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence.

  7. Sirt1 may down-regulate pig preadipocytes proliferation and differentiation through repression of adipocyte genes or FoxO1 (显示 FOXO1 抗体).

  8. The full-length complementary DNA sequence of porcine Sirt1 was 4,024 bp (GenBank accession no: EU030283), with a 2,226-bp open reading frame encoding a 742-AA protein

  9. Downregulation of miR (显示 MYLIP 抗体)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

  10. Sirt1 regulates the expression of FABP3 (显示 FABP3 抗体) gene in adipocytes, and PPAR gamma (显示 PPARG 抗体) apparently plays an important role in this process.

Cow (Bovine) Sirtuin 1 (SIRT1) interaction partners

  1. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. These results suggest that the SIRT1 gene could be used in marker assisted selection to improve the production traits of Qinchuan cattle.

  3. Downregulation of SIRT1 and FoxO1 (显示 FOXO1 抗体) were observed in the backfat tissue of Lilu cattle with increasing age. SIRT1 may play an important role in the development of bovine adipose tissue.

  4. Study indicates that a variation in the SIRT1 gene, the c.-274G variant in the promoter region, is associated with greater body size in Nanyang cattle.

  5. 5 novel SNPs were found in SIRT1. SNP g.-274C>G was shown to have association with 24-months-old body weight and g.17379A>G polymorphism was significantly related to 6 and 12-months-old body weight in NY population; results provide evidence that polymorphisms in SIRT1 are associated with growth efficiency traits

  6. The expression profile of sirtuin 1 and sirtuin 3 (显示 SIRT3 抗体) in the liver, muscle, and adipose tissue of calves and bulls is reported.

SIRT1 抗原简介

Antigen Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with SIRT1

  • sirtuin 1 (SIRT1) 抗体
  • sirtuin 1 (SRT1) 抗体
  • sirtuin 1 (LOC100349271) 抗体
  • sirtuin 1 (Sirt1) 抗体
  • sirtuin 1 (sirt1) 抗体
  • AA673258 抗体
  • SIR2 抗体
  • Sir2a 抗体
  • Sir2alpha 抗体
  • sir2l1 抗体
  • sirtuin 抗体
  • sirtuin 1 抗体

Protein level used designations for anti-Sirtuin 1 (SIRT1) 抗体

sirtuin 1 , NAD-dependent deacetylase sirtuin-1 , NAD-dependent protein deacetylase sirtuin-1 , SIR2-like protein 1 , mSIR2a , regulatory protein SIR2 homolog 1 , sir2-like 1 , sirtuin 1 ((silent mating type information regulation 2, homolog) 1 , SIR2alpha , hSIR2 , hSIRT1 , sirtuin type 1 , sirtuin (silent mating type information regulation 2 homolog) 1 , NAD-dependent deacetylase sirtuin 1 , sirtuin1 , Sir2alpha

100072571 Equus caballus
835670 Arabidopsis thaliana
100349271 Oryctolagus cuniculus
100540948 Meleagris gallopavo
100605499 Nomascus leucogenys
93759 Mus musculus
23411 Homo sapiens
100036963 Xenopus laevis
423646 Gallus gallus
489012 Canis lupus familiaris
751859 Sus scrofa
309757 Rattus norvegicus
101087610 Felis catus
613629 Bos taurus
anti-SIRT1 (SIRT1) 抗体 精选生产商