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MAP3K4 抗体

(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
MAP3K4 抗体 MAP3K4 抗体 MAP3K4 抗体 (ABIN7268653)

MAP3K4 适用: 人 IHC, WB 宿主: 兔 Monoclonal unconjugated

MAP3K4 抗体  (AA 1201-1300) MAP3K4 抗体  (AA 1201-1300) MAP3K4 抗体 (AA 1201-1300) (ABIN561801)

MAP3K4 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 4F10 unconjugated

MAP3K4 抗体  (AA 1-100) MAP3K4 抗体  (AA 1-100) MAP3K4 抗体 (AA 1-100) (ABIN7268654)

MAP3K4 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated

MAP3K4 抗体 by 适用

Find MAP3K4 抗体 for a variety of species such as anti-Human MAP3K4, anti-Mouse MAP3K4, anti-Rat MAP3K4. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find MAP3K4 抗体 validated for a specific application such as ELISA, WB, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find MAP3K4 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

MAP3K4 抗体 by 克隆形成能力

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Find MAP3K4 抗体 with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular MAP3K4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, WB
Validations
  • (5)
Cat. No. ABIN7268653
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IHC (p)
Validations
  • (4)
Cat. No. ABIN561801
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, WB
Validations
  • (4)
Cat. No. ABIN7268654
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, PLA
Validations
  • (3)
Cat. No. ABIN561800
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7160041
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN561802
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC, WB
Validations
  • (1)
Cat. No. ABIN6263107
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, WB
Validations
  • (2)
Cat. No. ABIN7300964
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN5534485
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN953298
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC
Validations
Cat. No. ABIN1386592
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN1393891
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF (cc), IF (p)
Validations
Cat. No. ABIN1393888
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF (cc), IF (p)
Validations
Cat. No. ABIN1393887
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF (cc), IF (p)
Validations
Cat. No. ABIN1393889
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our MAP3K4 抗体

Wong, Luo, Deng, Zou, Ye, Lin: "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39366-73, (2004) (PubMed).

Luo, Ng, Jin, Ye, Han, Lin: "Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37451-8, (2003) (PubMed).

Kovalsky, Lung, Roller, Fornace: "Oligomerization of human Gadd45a protein." in: The Journal of biological chemistry, Vol. 276, Issue 42, pp. 39330-9, (2001) (PubMed).

Aliases for MAP3K4 抗体

mitogen activated protein kinase kinase kinase 4 (Map3k4) 抗体
mitogen-activated protein kinase kinase kinase 4 (MAP3K4) 抗体
mitogen-activated protein kinase kinase kinase 4 (Map3k4) 抗体
D17Rp17 抗体
D17Rp17e 抗体
MAPKKK4 抗体
Mek4b 抗体
MEKK4 抗体
MEKK 4 抗体
Mekk4 抗体
mKIAA0213 抗体
MTK1 抗体
PRO0412 抗体
RP17 抗体
Rp17a 抗体
Tas 抗体
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