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- 抗原 See all MAP3K4 抗体
- MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
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抗原表位
- AA 1067-1097
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MAP3K4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This MEKK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1067-1097 amino acids from the Central region of human MEKK4.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product MAP3K4 Primary Antibody
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anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibody
MAP3K4 适用: 人 ELISA, WB, IHC (p) 宿主: 小鼠 Monoclonal 4F10 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1-100) antibodyMAP3K4 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibodyMAP3K4 适用: 人 ELISA, WB, PLA 宿主: 小鼠 Monoclonal 6A12 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 53-145) antibodyMAP3K4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1201-1300) antibodyMAP3K4 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 5D4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (N-Term) antibodyMAP3K4 适用: 人, 小鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (C-Term) antibodyMAP3K4 适用: 人, 小鼠, 大鼠 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) (AA 1065-1097), (Middle Region) antibodyMAP3K4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
- 别名
- MEKK4 (MAP3K4 产品)
- 别名
- MAPKKK4 antibody, MEKK4 antibody, MTK1 antibody, PRO0412 antibody, D17Rp17 antibody, D17Rp17e antibody, MEKK 4 antibody, Mek4b antibody, Mekk4 antibody, RP17 antibody, Rp17a antibody, Tas antibody, mKIAA0213 antibody, mitogen activated protein kinase kinase kinase 4 antibody, mitogen-activated protein kinase kinase kinase 4 antibody, Map3k4 antibody, MAP3K4 antibody
- 背景
- The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.
- 分子量
- 182 kDa
- 基因ID
- 4216
- UniProt
- Q9Y6R4
- 途径
- MAPK Pathway
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