anti-MAP2K4 (MAP2K4) 抗体产品概述

Full name:
anti-Mitogen-Activated Protein Kinase Kinase 4 抗体 (MAP2K4)
在www.antibodies-online.cn可供327 Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) 抗体的29不同的供货商。 再加上,我们可以发MAP2K4 蛋白 (11)MAP2K4 试剂盒 (8)和数多这个蛋白质的别的产品。 总共365 MAP2K4产品已列进来了。
别名:
2, 142758_at, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, CG9738, CT27508, CT38386, D-MKK4, DmelCG12798, Dmel\\CG9738, dMkk4, F19C24.26, F19C24_26, hep, JNKK, JNKK1, Jnkk2, map2k4, MAP KINASE KINASE 4, MAPKK4, Mapkk7, MEK4, Mek7, mitogen-activated protein kinase kinase 4, MKK4, MKK4A-l, Mkk7, Mpk4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SEK1/MKK4, Serk1, SKK1, xmek2, zgc:136500
列出全部抗体 基因 基因ID UniProt
MAP2K4 287398  
MAP2K4 6416 P45985
MAP2K4 26398 P47809

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引用最多的anti-MAP2K4 抗体

  1. Human Polyclonal MAP2K4 Primary Antibody for IHC, ELISA - ABIN1531968 : Lin, Minden, Martinetto, Claret, Lange-Carter, Mercurio, Johnson, Karin: Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 2 references for 1531968

  2. Human Polyclonal MAP2K4 Primary Antibody for IF, IHC (p) - ABIN197322 : Wang, Chen, Liao, Deng, Zhou, Huang, Sun: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. in Molecular and cellular biology 2002 (PubMed)
    Show all 2 references for 197322

  3. Human Monoclonal MAP2K4 Primary Antibody for FACS, IHC - ABIN969268 : Song, Coffa, Fu, Gurevich: How does arrestin assemble MAPKs into a signaling complex? in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for 969268

  4. Human Polyclonal MAP2K4 Primary Antibody for IHC (p), WB - ABIN658838 : Finegan, Tournier: The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer. in Cancer research 2010 (PubMed)
    Show all 2 references for 658838

  5. Human Polyclonal MAP2K4 Primary Antibody for ELISA, WB - ABIN1533737 : Dérijard, Raingeaud, Barrett, Wu, Han, Ulevitch, Davis: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. in Science (New York, N.Y.) 1995 (PubMed)
    Show all 2 references for 1533737

  6. Human Polyclonal MAP2K4 Primary Antibody for IF, IHC (p) - ABIN196908 : Leung, Lassam: The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for 196908

  7. Human Polyclonal MAP2K4 Primary Antibody for IF, IHC (p) - ABIN196910 : Park, Kim, Huh, Park, Chung, Kang, Choi: Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. in The Journal of biological chemistry 2002 (PubMed)

更多抗MAP2K4的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. in Drosophila both MAPKKs, Hep/Mkk7 (显示 MAP2K7 抗体) and Mkk4, are required to induce JNK (显示 MAPK8 抗体) upon TNF (显示 TNF 抗体) or pro-inflammatory stimulation

Human Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. MKK4 activates non-canonical NFkappaB (显示 NFKB1 抗体) signaling by promoting NFkappaB2-p100 (显示 CUX1 抗体) processing.

  2. Manipulating the expression of both miR (显示 MLXIP 抗体)-222 and miR (显示 MLXIP 抗体)-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR (显示 MLXIP 抗体)-25 reduced MEK4 and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR (显示 MLXIP 抗体)-25 functioning in thyroid cells.

  3. These results suggest that ROCK may be important in IL-1 (显示 IL1A 抗体)-induced signaling through MKK4 to JNK (显示 MAPK8 抗体) and the activation of p38 MAPK (显示 MAPK14 抗体).

  4. Association between MKK4 promoter polymorphism and breast cancer risk in Kashmiri population

  5. In Chinese Han ischemic stroke patients rs3826392 C/A genotype carriers showed significantly higher IL-1b (显示 IL1B 抗体) serum levels.

  6. The plasma level of protein MAP2K4 was found to suggestively associate negatively with the volume of the left entorhinal cortex in asymptomatic older twins.

  7. MAP2K4 increases human prostate cancer metastasis, and prolonged over expression induces long term changes in cell signaling pathways leading to independence from p38 MAPK (显示 MAPK14 抗体) and JNK (显示 MAPK8 抗体).

  8. MKK4 is activated in vitro by reduced Trx (显示 VAC14 抗体) but not oxidized Trx (显示 VAC14 抗体) in the absence of an upstream kinase, suggesting that autophosphorylation of this protein occurs due to reduction of Cys (显示 DNAJC5 抗体)-246 and Cys (显示 DNAJC5 抗体)-266 by Trx (显示 VAC14 抗体).

  9. Data suggest a genetic interaction between MAP2K4 and HLA-DRB1 (显示 HLA-DRB1 抗体), and the importance of rs10468473 and MAP2K4 splice variants in the development of autoantibody-positive RA.

  10. knockdown of Sec8 (显示 EXOC4 抗体) enhances the binding of JIP4 (显示 SPAG9 抗体) to MAPK (显示 MAPK1 抗体) kinase 4, thereby decreasing the phosphorylation of MAPK (显示 MAPK1 抗体) kinase 4, JNK (显示 MAPK8 抗体), and p38 (显示 CRK 抗体).

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 (显示 PATL2 抗体) processing.

  2. Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 (显示 TGFB1 抗体) signaling associated with atrial remodeling and arrhythmogenesis with age.

  3. This study provides compelling evidence for the pivotal roles of the ZPK/DLK (显示 MAP3K12 抗体) and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates.

  4. The loss of mkk4 and mkk7 (显示 MAP2K7 抗体) locks damaged exocrine cells in a permanently de-differentiated state.

  5. Studies identify the dual-specific kinase MKK4 as a master regulator of liver regeneration. MKK4 silencing robustly increased the regenerative capacity of hepatocytes in mouse models of liver regeneration and acute and chronic liver failure.

  6. MicroRNA-92a negatively regulates Toll (显示 TLR4 抗体)-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase

  7. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.

  8. MKK4/7 and JNK1 (显示 MAPK8 抗体)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.

  9. These data support a model in which MKK4 activation at the metastatic site causes a cell-cycle arrest.

  10. Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 (显示 GJA1 抗体) reduction and couples hypertrophic signals to ventricular arrhythmogenesis.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) interaction partners

  1. MKK4, MKK5 (显示 MAP2K5 抗体), MKK7 (显示 MAP2K7 抗体), and MKK9, are responsible for the activation of MPK3 (显示 MAPK3 抗体) and MPK6 (显示 MAPK6 抗体) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 抗体) signaling through MKK4/5/7/9-MPK3 (显示 MAPK3 抗体)/6 cascades.

  2. our data indicate that EDR1 (显示 PHC1 抗体) physically associates with MKK4/MKK5 (显示 MAP2K5 抗体) and negatively regulates the MAPK (显示 MAPK1 抗体) cascade to fine-tune plant innate immunity.

  3. Results suggest that the YDA-MKK4/MKK5 (显示 MAP2K5 抗体)-MPK3 (显示 MAPK3 抗体)/MPK6 (显示 MAPK6 抗体) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.

  4. MKK4 is involved in the osmotic-stress response via its regulation of MPK3 (显示 MAPK3 抗体) activity.

  5. MKK4 is a key regulator of stomatal development and patterning.

MAP2K4 抗原简介

Antigen Summary

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.

Alternative names and synonyms associated with MAP2K4

  • mitogen-activated protein kinase kinase 4 (map2k4) 抗体
  • MAP kinase kinase 4 (Mkk4) 抗体
  • CG12798 (CG12798) 抗体
  • mitogen activated protein kinase kinase 4 (Map2k4) 抗体
  • mitogen activated protein kinase kinase 7 (Map2k7) 抗体
  • mitogen-activated protein kinase kinase 4 (MAP2K4) 抗体
  • mitogen-activated protein kinase kinase 4 (Map2k4) 抗体
  • mitogen-activated protein kinase kinase 4 (MKK4) 抗体
  • mitogen-activated protein kinase kinase 4a (map2k4a) 抗体
  • 2 抗体
  • 142758_at 抗体
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 抗体
  • ATMEK4 抗体
  • ATMKK4 抗体
  • CG9738 抗体
  • CT27508 抗体
  • CT38386 抗体
  • D-MKK4 抗体
  • DmelCG12798 抗体
  • Dmel\\CG9738 抗体
  • dMkk4 抗体
  • F19C24.26 抗体
  • F19C24_26 抗体
  • hep 抗体
  • JNKK 抗体
  • JNKK1 抗体
  • Jnkk2 抗体
  • map2k4 抗体
  • MAP KINASE KINASE 4 抗体
  • MAPKK4 抗体
  • Mapkk7 抗体
  • MEK4 抗体
  • Mek7 抗体
  • mitogen-activated protein kinase kinase 4 抗体
  • MKK4 抗体
  • MKK4A-l 抗体
  • Mkk7 抗体
  • Mpk4 抗体
  • PRKMK4 抗体
  • SAPKK-1 抗体
  • SAPKK1 抗体
  • SEK1 抗体
  • SEK1/MKK4 抗体
  • Serk1 抗体
  • SKK1 抗体
  • xmek2 抗体
  • zgc:136500 抗体

Protein level used designations for MAP2K4

CG9738-PA , CG9738-PB , CG9738-PC , JNK kinase 2 , Map kinase kinase 4 , Mkk4-PA , Mkk4-PB , Mkk4-PC , drosophila MAP kinase kinase 4 , CG12798 , CG12798-PA , MAP2K4delta , SAPK/ERK kinase 1 , dual specificity mitogen-activated protein kinase kinase 4 , JNK-activating kinase 2 , JNKK 2 , MAP kinase kinase 7 , MAPK/ERK kinase 7 , MAPKK 7 , MEK 7 , c-Jun N-terminal kinase kinase 2 , dual specificity mitogen-activated protein kinase kinase 7 , JNK activating kinase 1 , JNK-activated kinase 1 , JNK-activating kinase 1 , MAP kinase kinase 4 , MAPK/ERK kinase 4 , MAPKK 4 , MEK 4 , c-Jun N-terminal kinase kinase 1 , stress-activated protein kinase kinase 1 , C-JUN N-terminal kinase kinase 1 , JNK kinase 1 , JNKK 1 , SAPK/Erk/kinase 1 , mitogen activated protein kinase kinase 4, variant 1 , mitogen-activated protein kinase kinase 4 , mkk4a

GENE ID SPECIES
100135013 Xenopus (Silurana) tropicalis
41020 Drosophila melanogaster
3355004 Drosophila melanogaster
287398 Rattus norvegicus
363855 Rattus norvegicus
6416 Homo sapiens
26398 Mus musculus
489508 Canis lupus familiaris
841591 Arabidopsis thaliana
403052 Danio rerio
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