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抗Mouse (Murine) 抗体:
Human Polyclonal SMARCA4 Primary Antibody for ChIP, ICC - ABIN4285245
Miyamoto, Pasque, Jullien, Gurdon: Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. in Genes & development 2011
Show all 4 Pubmed References
Human Polyclonal SMARCA4 Primary Antibody for WB - ABIN686122
Chen, Han, Wei, Zhang, Shi, Duan, Li, Zhou, Pu, Zhang, Kang: SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma. in Scientific reports 2015
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668499
Ohkawa, Harada, Nakamura, Yoshimura, Tachibana: Production of a rat monoclonal antibody against Brg1. in Hybridoma (2005) 2009
Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668498
de la Serna, Ohkawa, Higashi, Dutta, Osias, Kommajosyula, Tachibana, Imbalzano: The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. in The Journal of biological chemistry 2006
The vast majority of SCCOHT demonstrate genomic SMARCA4 loss with only rare co-occurring alterations. Data support a role for CGP in the diagnosis and management of SCCOHT and of other lesions with overlapping histological and clinical features, since identifying the former by genomic profile suggests benefit from an appropriate regimen and treatment decisions.
BRG1 can promote VEGF-A (显示 VEGFA 抗体) expression and angiogenesis in colorectal cancer and BRG1 may be a novel drug target for the treatment of colorectal cancer.
The BRG1/SIRT1 (显示 SIRT1 抗体)/p53 (显示 TP53 抗体) signal axis is a novel mechanism of cell senescence in CRC (显示 CALR 抗体).
BRG1 and SMARCAL1 (显示 SMARCAL1 抗体), members of the ATP-dependent chromatin remodelling family, are shown to co-regulate the transcription of DROSHA (显示 DROSHA 抗体), DGCR8 (显示 DGCR8 抗体), and DICER (显示 DICER1 抗体) in response to double-strand DNA breaks.
BRG1 was significantly increased in hepatocellular carcinoma. Overexpression of BRG1 increases cell growth and invasiveness in HCC (显示 FAM126A 抗体).
Case Report: SMARCA4 nonsense/frameshift mutations responsible for concomitant Coffin-Siris syndrome, microphthalmia and small-cell carcinoma of the ovary hypercalcaemic type.
i-motif structures in long cytosine-rich sequences found upstream of the promoter region of the SMARCA4 gene
Brg1 coordinates a genetic and epigenetic network that regulates the transcriptional program underlying the Shh (显示 SHH 抗体)-type medulloblastoma development.
whole-genome transcriptome analysis revealed that BRG1 controls the expression of key elements of oncogenic pathways such as PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) and BCL2 (显示 BCL2 抗体), which offers a promising new combination therapy for high-risk Neuroblastoma (显示 ARHGEF16 抗体) (NB).
A breakdown in a BRCA/FANCD2 (显示 FANCD2 抗体)/BRG1/SNF (显示 SNRPA 抗体)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.
BRG1 is a SOX10 (显示 SOX10 抗体) co-activator, required to establish the melanocyte lineage and promote expression of genes important for melanocyte function.
n keratinocytes, the promoter-enhancer anchoring regions in the gene-rich transcriptionally active TADs are enriched for the binding of chromatin architectural proteins CTCF (显示 CTCF 抗体), Rad21 (显示 RAD21 抗体) and chromatin remodeler Brg1. In contrast to gene-rich TADs, gene-poor TADs show preferential spatial contacts with each other, do not contain active enhancers and show decreased binding of CTCF (显示 CTCF 抗体), Rad21 (显示 RAD21 抗体) and Brg1 in keratinocytes
Data demonstrate that Brg1 plays an essential role in development and homeostasis, including morphogenesis, stem cell differentiation and cell survival in the duodenum.
Point mutations in SMARCA4 (also known as BRG1) mapping to the ATPase (显示 DNAH8 抗体) domain cause loss of direct binding between BAF (显示 BANF1 抗体) and PRC1 (显示 PRC1 抗体).
BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.
RB is necessary for the recruitment of the BRG1 ATPase (显示 DNAH8 抗体) to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination
Cdx (显示 CDX1 抗体) members interact with the SWI (显示 SMARCA1 抗体)-SNF (显示 SNRPA 抗体) complex and make direct contact with Brg1, a catalytic member of SWI (显示 SMARCA1 抗体)-SNF (显示 SNRPA 抗体). Both Cdx2 (显示 CDX2 抗体) and Brg1 co-occupy a number of Cdx (显示 CDX1 抗体) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 (显示 CDX2 抗体) and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.
BRG1/BRM (显示 SMARCA2 抗体) and c-MYC (显示 MYC 抗体) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (显示 RAB1A 抗体) in cancer.
Results provide insights into the mechanisms by which Brg1 functions, which is in part via the p53 (显示 TP53 抗体) program, to constrain gene expression and facilitate rapid embryonic growth.
Brg1 promotes neurogenic radial glial progenitor cell specification but is dispensable for neuronal differentiation
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
, transcription activator BRG1-like
, ATP-dependent helicase SMARCA4
, BRG1-associated factor 190A
, BRM/SWI2-related gene 1
, SNF2-like 4
, brahma protein-like 1
, global transcription activator homologous sequence
, homeotic gene regulator
, mitotic growth and transcription activator
, nuclear protein GRB1
, protein BRG-1
, protein brahma homolog 1
, sucrose nonfermenting-like 4
, transcription activator BRG1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
, SWI/SNF related transcriptional activator
, WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4