anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) 抗体产品概述

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anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 抗体 (SMARCA4)
在www.antibodies-online.cn可供100 SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) 抗体的24不同的供货商。 再加上,我们可以发SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 蛋白 (7)SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 试剂盒 (1)和数多这个蛋白质的别的产品。 总共109 SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4产品已列进来了。
别名:
b2b692Clo, BAF190, BAF190A, brg-1, Brg1, HP1-BP72, hSNF2b, MRD16, RTPS2, SMARCA4, SNF2, SNF2beta, SNF2L4, SNF2LB, SW1/SNF, SWI2
列出全部抗体 基因 基因ID UniProt
SMARCA4 6597 P51532
SMARCA4 171379  
SMARCA4 20586 Q3TKT4

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引用最多的anti-SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 抗体

  1. Human Polyclonal SMARCA4 Primary Antibody for ChIP, ICC - ABIN4285245 : Miyamoto, Pasque, Jullien, Gurdon: Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. in Genes & development 2011 (PubMed)
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  2. Human Monoclonal SMARCA4 Primary Antibody for WB - ABIN343708 : Griffin, Brennan, Magnuson: The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. in Development (Cambridge, England) 2008 (PubMed)
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  3. Human Monoclonal SMARCA4 Primary Antibody for IHC (p), WB - ABIN614772 : Ooi, Belyaev, Miyake, Wood, Buckley: BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression. in The Journal of biological chemistry 2006 (PubMed)
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  4. Human Polyclonal SMARCA4 Primary Antibody for WB - ABIN871762 : Park, Venteicher, Hong, Choi, Jun, Shkreli, Chang, Meng, Cheung, Ji, McLaughlin, Veenstra, Nusse, McCrea, Artandi: Telomerase modulates Wnt signalling by association with target gene chromatin. in Nature 2009 (PubMed)
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  5. Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668499 : Ohkawa, Harada, Nakamura, Yoshimura, Tachibana: Production of a rat monoclonal antibody against Brg1. in Hybridoma (2005) 2009 (PubMed)

  6. Human Polyclonal SMARCA4 Primary Antibody for WB - ABIN686122 : Chen, Han, Wei, Zhang, Shi, Duan, Li, Zhou, Pu, Zhang, Kang: SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma. in Scientific reports 2015 (PubMed)

  7. Human Monoclonal SMARCA4 Primary Antibody for ICC, IF - ABIN2668498 : de la Serna, Ohkawa, Higashi, Dutta, Osias, Kommajosyula, Tachibana, Imbalzano: The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes. in The Journal of biological chemistry 2006 (PubMed)

更多抗SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4的相互作用对抗体

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) interaction partners

  1. BRG1 was significantly increased in hepatocellular carcinoma. Overexpression of BRG1 increases cell growth and invasiveness in HCC (显示 FAM126A 抗体).

  2. Case Report: SMARCA4 nonsense/frameshift mutations responsible for concomitant Coffin-Siris syndrome, microphthalmia and small-cell carcinoma of the ovary hypercalcaemic type.

  3. i-motif structures in long cytosine-rich sequences found upstream of the promoter region of the SMARCA4 gene

  4. Brg1 coordinates a genetic and epigenetic network that regulates the transcriptional program underlying the Shh (显示 SHH 抗体)-type medulloblastoma development.

  5. whole-genome transcriptome analysis revealed that BRG1 controls the expression of key elements of oncogenic pathways such as PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) and BCL2 (显示 BCL2 抗体), which offers a promising new combination therapy for high-risk Neuroblastoma (显示 ARHGEF16 抗体) (NB).

  6. A breakdown in a BRCA/FANCD2 (显示 FANCD2 抗体)/BRG1/SNF (显示 SNRPA 抗体)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.

  7. both ABCB1 (显示 ABCB1 抗体) upregulation and doxorubicin resistance caused by SMARCB1 (显示 SMARCB1 抗体) loss were dependent on the function of SMARCA4, a catalytic subunit of the SWI (显示 SMARCA1 抗体)/SNF (显示 SNRPA 抗体) complex.

  8. BRG1 participates in gene repression by interacting with H1.2 (显示 HIST1H1C 抗体), facilitating its deposition and stabilizing nucleosome positioning around the transcription start site.

  9. Cdx (显示 CDX1 抗体) members interact with the SWI (显示 SMARCA1 抗体)-SNF (显示 SNRPA 抗体) complex and make direct contact with Brg1, a catalytic member of SWI (显示 SMARCA1 抗体)-SNF (显示 SNRPA 抗体). Both Cdx2 (显示 CDX2 抗体) and Brg1 co-occupy a number of Cdx (显示 CDX1 抗体) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 (显示 CDX2 抗体) and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.

  10. BRG1/BRM (显示 SMARCA2 抗体) and c-MYC (显示 MYC 抗体) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (显示 RAB1A 抗体) in cancer.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) interaction partners

  1. Data demonstrate that Brg1 plays an essential role in development and homeostasis, including morphogenesis, stem cell differentiation and cell survival in the duodenum.

  2. Point mutations in SMARCA4 (also known as BRG1) mapping to the ATPase (显示 DNAH8 抗体) domain cause loss of direct binding between BAF (显示 BANF1 抗体) and PRC1 (显示 PRC1 抗体).

  3. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  4. RB is necessary for the recruitment of the BRG1 ATPase (显示 DNAH8 抗体) to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination

  5. Cdx (显示 CDX1 抗体) members interact with the SWI (显示 SMARCA1 抗体)-SNF (显示 SNRPA 抗体) complex and make direct contact with Brg1, a catalytic member of SWI (显示 SMARCA1 抗体)-SNF (显示 SNRPA 抗体). Both Cdx2 (显示 CDX2 抗体) and Brg1 co-occupy a number of Cdx (显示 CDX1 抗体) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 (显示 CDX2 抗体) and Brg1 occupancy occurs coincident with chromatin remodeling at some of these loci.

  6. BRG1/BRM (显示 SMARCA2 抗体) and c-MYC (显示 MYC 抗体) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (显示 RAB1A 抗体) in cancer.

  7. Results provide insights into the mechanisms by which Brg1 functions, which is in part via the p53 (显示 TP53 抗体) program, to constrain gene expression and facilitate rapid embryonic growth.

  8. Brg1 promotes neurogenic radial glial progenitor cell specification but is dispensable for neuronal differentiation

  9. SWI (显示 SMARCA1 抗体)/SNF (显示 SNRPA 抗体) chromatin remodeler subunits Brg1 and Brm (显示 SMARCA2 抗体) are expressed differentially during drug-induced liver injury and regeneration in a mouse model.

  10. these findings described a role for BRG1 and BRM (显示 SMARCA2 抗体) in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4)

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4) 抗体
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Smarca4) 抗体
  • b2b692Clo 抗体
  • BAF190 抗体
  • BAF190A 抗体
  • brg-1 抗体
  • Brg1 抗体
  • HP1-BP72 抗体
  • hSNF2b 抗体
  • MRD16 抗体
  • RTPS2 抗体
  • SMARCA4 抗体
  • SNF2 抗体
  • SNF2beta 抗体
  • SNF2L4 抗体
  • SNF2LB 抗体
  • SW1/SNF 抗体
  • SWI2 抗体

Protein level used designations for SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 , transcription activator BRG1-like , ATP-dependent helicase SMARCA4 , BRG1-associated factor 190A , BRM/SWI2-related gene 1 , SNF2-beta , SNF2-like 4 , brahma protein-like 1 , global transcription activator homologous sequence , homeotic gene regulator , mitotic growth and transcription activator , nuclear protein GRB1 , protein BRG-1 , protein brahma homolog 1 , sucrose nonfermenting-like 4 , transcription activator BRG1 , BAF190A , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 , SWI/SNF related transcriptional activator , WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

GENE ID SPECIES
455720 Pan troglodytes
476710 Canis lupus familiaris
100415454 Callithrix jacchus
100446301 Pongo abelii
100464834 Ailuropoda melanoleuca
6597 Homo sapiens
171379 Rattus norvegicus
20586 Mus musculus
414274 Bos taurus
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