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|抗原||Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) 抗体|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This EIF2AK2 antibody is un-conjugated 其他选择|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
EIF2AK2抗体详情EIF2AK2目标详情 使用细节 贮存及处理 图像
|特异性||This antibody detects PKR at C-term.|
|交叉反应 （详细）||Species reactivity (tested):Human, mouse, rat|
|纯化方法||Peptide affinity chromatography|
|免疫原||PKR antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PKR.|
EIF2AK2目标详情EIF2AK2抗体详情 使用细节 贮存及处理 图像 回页首
|别名||EIF2AK2 / PKR (EIF2AK2 Antibody 摘要)|
|背景||The interferon-inducible, double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family, possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system. Upon binding dsRNA, PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2, resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 2, Interferon-induced double-stranded RNA-activated protein kinase, PRKR, Protein kinase RNA-activated, eIF-2A protein kinase 2, p68 kinase|
|途径||ER-Nucleus Signaling, Hepatitis C|
使用细节EIF2AK2抗体详情 EIF2AK2目标详情 贮存及处理 图像 回页首
ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
贮存及处理EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 图像 回页首
|缓冲液||PBS containing 0.02 % sodium azide|
|注意事项||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|注意事项||Avoid repeated freezing and thawing.|
|储存条件||4 °C/-20 °C|
|储存方法||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.|