anti-小鼠 EIF2AK2 抗体 for Enzyme Immunoassay

Recommended EIF2AK2 Antibody (supplied by: Log in to see )

抗原
Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) 抗体
  • PKR
  • pkr
  • EIF2AK2
  • DKFZp469K1934
  • EIF2AK1
  • PRKR
  • 2310047A08Rik
  • 4732414G15Rik
  • AI467567
  • AI747578
  • Pkr
  • Prkr
  • Tik
  • eukaryotic translation initiation factor 2-alpha kinase 2
  • EIF2AK2
  • eif2ak2
  • Eif2ak2
抗原表位
C-Term
61
54
25
19
18
15
15
13
12
6
5
4
4
4
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠
291
82
43
2
2
2
2
1
1
1
1
宿主

248
47
克隆类型
多克隆
标记
This EIF2AK2 antibody is un-conjugated
7
7
6
5
5
4
4
4
4
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
189
128
99
80
49
46
19
15
4
3
2
1
1
Supplier
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产品编号 ABIN360664
4,780.92 ¥
(含税, 含运费)
来自4A Biotech Co.,Ltd.(本地经销商)
获取报价
中国 北京 101111
No. 88 KeChuang 6th Street
Room 801-803
Beijing Economic Technological Development Area
4A Biotech Co.,Ltd.
Tel 400-7060-959
传真 +86 10 56315212-8813
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN360663 EIA IHC (p) WB Rabbit Ig N-Term Log in to see Polyclonal 5
1 ABIN5555126 EIA IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal
1 ABIN5555127 EIA IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal

引用最多的anti-EIF2AK2 抗体 for Enzyme Immunoassay

Similar anti-EIF2AK2 抗体

应用范围 / 适用 小鼠
ELISA 19 抗体 95 抗体
Enzyme Immunoassay (EIA) 4 抗体 4 抗体
Immunocytochemistry (ICC) 1 抗体 15 抗体
Immunofluorescence (IF) 8 抗体 46 抗体
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 10 抗体 49 抗体
Immunohistochemistry (IHC) 46 抗体 128 抗体
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 22 抗体
Western Blotting (WB) 54 抗体
Cytometry by Time of Flight (CyTOF) 1 抗体
Flow Cytometry (FACS) 19 抗体
Immunochromatography (IC) 1 抗体
Immunofluorescence (fixed cells) (IF/ICC) 2 抗体

General

抗原 Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) 抗体
抗原表位 C-Term
(61), (54), (25), (19), (18), (15), (15), (13), (12), (6), (5), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 人, 小鼠
(291), (82), (43), (2), (2), (2), (2), (1), (1), (1), (1)
宿主
(248), (47)
克隆类型
多克隆
标记 This EIF2AK2 antibody is un-conjugated
(7), (7), (6), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
应用范围 Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(189), (128), (99), (80), (49), (46), (19), (15), (4), (3), (2), (1), (1)
Pubmed 5个引用可参考
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EIF2AK2抗体详情

EIF2AK2目标详情 使用细节 贮存及处理 ProductDetails: References for anti-EIF2AK2 antibody (ABIN360664) 图像
特异性 This antibody reacts to PRKR.
纯化方法 Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
免疫原 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PRKR.
亚型 Ig

EIF2AK2目标详情

EIF2AK2抗体详情 使用细节 贮存及处理 ProductDetails: References for anti-EIF2AK2 antibody (ABIN360664) 图像 回页首
抗原
别名 EIF2AK2 / PKR (EIF2AK2 Antibody 摘要)
背景 Interferon-induced, double-stranded RNA-activated protein kinase (PRKR) is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PRKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. Human gamma-interferon (IFNG) mRNA exploits localized activation of PRKR in the cell to regulate its own translation. IFNG mRNA activates PRKR through a pseudoknot in its 5-prime untranslated region. The HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PRKR and the translation initiation factor EIF2-alpha, a target of PRKR. E2 inhibits the kinase activity of PRKR and blocks its inhibitory effect on protein synthesis and cell growth, which provides one mechanism by which HCV may circumvent the antiviral effect of interferon. PRKR, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, also activates IKK and NFKB, thereby suppressing apoptosis. Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PRKR, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system. Roles for PRKR activation in Huntington disease and Fanconi anemia have also been suggested.Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 2, Interferon-induced double-stranded RNA-activated protein kinase, PRKR, Protein kinase RNA-activated, eIF-2A protein kinase 2, p68 kinase
基因ID 5610
NCBI登录号 NP_001129123
UniProt P19525
途径 ER-Nucleus Signaling, Hepatitis C

使用细节

EIF2AK2抗体详情 EIF2AK2目标详情 贮存及处理 ProductDetails: References for anti-EIF2AK2 antibody (ABIN360664) 图像 回页首
应用备注 ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Flow cytometry.
限制 仅限研究用

贮存及处理

EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 ProductDetails: References for anti-EIF2AK2 antibody (ABIN360664) 图像 回页首
状态 Liquid
浓度 0.25 mg/mL
缓冲液 PBS with 0.09 % (W/V) sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

ProductDetails: References for anti-EIF2AK2 antibody (ABIN360664)

EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 贮存及处理 图像 回页首
背景

Peel, Bredesen: "Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice." in: Neurobiology of disease, Vol. 14, Issue 1, pp. 52-62, 2003

Pang, Christianson, Keeble, Koretsky, Bagby: "The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49638-43, 2002

Kim, Gunnery, Choe, Mathews: "Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR." in: Oncogene, Vol. 21, Issue 57, pp. 8741-8, 2002

Takizawa, Tatematsu, Nakanishi: "Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways." in: European journal of biochemistry / FEBS, Vol. 269, Issue 24, pp. 6126-32, 2002

Peters, Khoo, Mohr, Sen: "Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein." in: Journal of virology, Vol. 76, Issue 21, pp. 11054-64, 2002

图像

EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 贮存及处理 ProductDetails: References for anti-EIF2AK2 antibody (ABIN360664) 回页首
厂商提供的图像
 image for anti-EIF2AK2 抗体 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2) (C-Term) (ABIN360664) anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (C-Term) antibody
 image for anti-EIF2AK2 抗体 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2) (C-Term) (ABIN360664) anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (C-Term) antibody (Image 2)