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Human Monoclonal AP2M1 Primary Antibody for IF, WB - ABIN968487
Ohno, Stewart, Fournier, Bosshart, Rhee, Miyatake, Saito, Gallusser, Kirchhausen, Bonifacino: Interaction of tyrosine-based sorting signals with clathrin-associated proteins. in Science (New York, N.Y.) 1995
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Human Monoclonal AP2M1 Primary Antibody for IF, WB - ABIN968488
Vecchi, Polo, Poupon, van de Loo, Benmerah, Di Fiore: Nucleocytoplasmic shuttling of endocytic proteins. in The Journal of cell biology 2001
Show all 2 Pubmed References
Dog (Canine) Monoclonal AP2M1 Primary Antibody for ICC, IF - ABIN4280926
Jia, Xu, Qian, Yao, Miao, Zheng, Liu, Guo, Geng, Qiao, Liang: Identification of an endocytic signal essential for the antiviral action of IFITM3. in Cellular microbiology 2014
AP2 (显示 GTF3A 抗体) has evolved as a key regulatory node to coordinate clarhtin-coated pit (显示 IRF6 抗体) formation and cargo sorting and ensure high spatial and temporal regulation of cathrin-mediated endocytosis.
BMCC1 (显示 PRUNE2 抗体) is an AP-2 (显示 GTF3A 抗体) associated endosomal protein in prostate cancer cells.
We identify dynamin and the EAP-binding alpha-adaptin appendage domain of the AP2 adaptor as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in clathrin mediated endocytosis.
a conserved heretofore unrecognized YXXPhi motif (Phi is a bulky hydrophobic residue) within the core protein. This motif is homologous to sorting signals within host cargo proteins known to mediate binding of AP2M1
Arkadia (显示 RNF111 抗体) complexes with clathrin adaptor AP2 (显示 GTF3A 抗体) mu2 subunit and regulates EGF (显示 EGF 抗体) signalling.
These results suggest that AP-2 (显示 GTF3A 抗体) is essential for endocytic clathrin coated-pit (显示 IRF6 抗体) and coated-vesicle formation.
multiple interactions between PIPKI gamma-p90 and AP-2 lead to spatiotemporally controlled PI(4,5)P(2) synthesis during clathrin-mediated synaptic vesicle endocytosis.
V1H can function as an adaptor for interactions between Nef and AP-2 (显示 GTF3A 抗体).
direct association of the adaptor complex 2 with a G protein-coupled receptor has not been reported so far and might represent a common mechanism underlying clathrin-mediated receptor endocytosis
Results indicate that AP-2 is not essential for clathrin-coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins.
Binding of AP-2 (显示 TFAP2A 抗体) to otoferlin (显示 OTOF 抗体) facilitates replenishment of release sites, for example, via speeding AZ clearance of exocytosed material, in addition to a role of AP-2 (显示 TFAP2A 抗体) in synaptic vesicle reformation.
Data shsow that mutation of residues at the DEP (显示 ZDHHC21 抗体)-mu2 contact or in the tyrosine motif reduce affinity of Dvl2 (显示 DVL2 抗体) for mu2.
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.
AP-2 complex subunit mu-1-A
, AP-2 complex subunit mu-A
, AP-2 mu-2 chain A
, AP-2 mu-A chain
, adaptor protein complex AP-2, mu1
, clathrin assembly protein complex 2 medium chain A
, clathrin coat assembly protein AP50-A
, clathrin coat-associated protein AP50-A
, plasma membrane adaptor AP-2 50 kDa protein A
, AP-2 complex subunit mu-1-B
, AP-2 complex subunit mu-B
, AP-2 mu-2 chain B
, AP-2 mu-B chain
, clathrin assembly protein complex 2 medium chain B
, clathrin coat assembly protein AP50-B
, clathrin coat-associated protein AP50-B
, plasma membrane adaptor AP-2 50 kDa protein B
, AP-2 complex subunit mu
, AP-2 complex subunit mu-1
, AP-2 mu chain
, AP-2 mu-2 chain
, clathrin assembly protein complex 2 medium chain
, clathrin coat assembly protein AP50
, clathrin coat-associated protein AP50
, plasma membrane adaptor AP-2 50 kDa protein
, adaptor-related protein complex 2, mu 1 subunit
, AP-2 complex subunit mu-like
, clathrin coat assembly protein ap50
, AP-2 mu 2 chain
, HA2 50 kDA subunit
, adapter-related protein complex 2 mu subunit
, adaptor protein complex AP-2 subunit mu
, clathrin adaptor complex AP2, mu subunit
, clathrin coat adaptor protein AP50
, clathrin-associated/assembly/adaptor protein, medium 1
, plasma membrane adaptor AP-2 50kDA protein
, adaptor-related protein complex AP-2, mu1
, clathrin-associated AP-2
, coat assembly protein complex 50 kD
, HA2 50 kDa subunit