anti-MSH6 (MSH6) 抗体产品概述

Full name:
anti-MutS Homolog 6 (E. Coli) 抗体 (MSH6)
在www.antibodies-online.cn可供151 MutS Homolog 6 (E. Coli) (MSH6) 抗体的23不同的供货商。 再加上,我们可以发MSH6 蛋白 (7)和数多这个蛋白质的别的产品。 总共163 MSH6产品已列进来了。
别名:
AU044881, AW550279, cb326, GTBP, Gtmbp, HNPCC5, HSAP, LOC100227810, p160, wu:fb36c12

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引用最多的anti-MSH6 抗体

  1. Dog (Canine) Monoclonal MSH6 Primary Antibody for IF, WB - ABIN968247 : Christmann, Kaina: Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents. in The Journal of biological chemistry 2000 (PubMed)
    Show all 5 references for 968247

  2. Human Polyclonal MSH6 Primary Antibody for ICC, IF - ABIN151794 : Cyr, Heinen: Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for 151794

  3. Human Monoclonal MSH6 Primary Antibody for ICC, FACS - ABIN969293 : Grindedal, Møller, Eeles, Stormorken, Bowitz-Lothe, Landrø, Clark, Kvåle, Shanley, Maehle: Germ-line mutations in mismatch repair genes associated with prostate cancer. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009 (PubMed)

  4. Human Monoclonal MSH6 Primary Antibody for ELISA, WB - ABIN969292 : Becker, Creagh, ONeill: Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. in The Journal of biological chemistry 2009 (PubMed)

  5. Human Polyclonal MSH6 Primary Antibody for ELISA, WB - ABIN1534473 : Palombo, Gallinari, Iaccarino, Lettieri, Hughes, DArrigo, Truong, Hsuan, Jiricny: GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. in Science (New York, N.Y.) 1995 (PubMed)

  6. Cow (Bovine) Polyclonal MSH6 Primary Antibody for IHC, WB - ABIN2776759 : Wedrén, Lovmar, Humphreys, Magnusson, Melhus, Syvänen, Kindmark, Landegren, Fermér, Stiger, Persson, Baron, Weiderpass: Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study. in BMC cancer 2009 (PubMed)

  7. Dog (Canine) Monoclonal MSH6 Primary Antibody for IHC (fro), IHC (p) - ABIN115272 : Schleger, Heck, Niketeghad, Schirmacher, Radaeva, Oesch, Dienes, Bannasch, Steinberg: Establishment and characterization of a nontumorigenic cell line derived from a human hepatocellular adenoma expressing hepatocyte-specific markers. in Experimental cell research 1997 (PubMed)

更多抗MSH6的相互作用对抗体

Zebrafish MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. Studied MSH6 gene expression in developing zebrafish and the influence of MSH6 expression on the production of mismatch binding factors.

  2. Identification and characterization of novel knockout mutants of the three major MMR (显示 MRC1 抗体) genes, mlh1 (显示 MLH1 抗体), msh2 (显示 MSH2 抗体), and msh6, in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. Neoadjuvant therapy in microsatellite-stable colorectal carcinoma induces concomitant loss of MSH6 and Ki-67 (显示 MKI67 抗体) expression.

  2. High MSH6 expression is associated with the development of genetic instability and is linked to tumor aggressiveness and early PSA (显示 PLAG1 抗体) recurrence in prostate cancer.

  3. human Pol alpha interacts with MSH2 (显示 MSH2 抗体)-MSH6 complex

  4. In colorectal neoplasms, negative expression of the MMR (显示 MRC1 抗体) proteins MLH1 (显示 MLH1 抗体), MSH2 (显示 MSH2 抗体) or MSH6 was seen in 15% (47 of 313) of the patients. Defect MLH1 (显示 MLH1 抗体) was most common and detected in 12% of the cases. Defect MLH1 (显示 MLH1 抗体) and MSH2 (显示 MSH2 抗体) were identified in each patient's normal adjacent mucosa.

  5. unlike MutSbeta, MutSalpha may also act to protect against repeat contractions in the Fmr1 (显示 FMR1 抗体) gene

  6. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (显示 MLH1 抗体) in 40%, MSH2 (显示 MSH2 抗体) in 36%, MSH6 in 18% and PMS2 (显示 PMS2 抗体) in 6% of the families

  7. There is a positive correlation between the expressions of hMSH2 (显示 MSH2 抗体) and hMSH6 between males (RHO=0.673 and p=0.001) and females with colorectal adenocarcinoma.

  8. Individuals with Lynch syndrome and double-mutants in MSH6 and MSH2 (显示 MSH2 抗体) had normal MSH2 (显示 MSH2 抗体) expression, whereas MSH6 immunoexpression was lost in all evaluable cases.

  9. we identified gene promoter methylation signatures (WT1 (显示 WT1 抗体), MSH6, GATA5 (显示 GATA5 抗体) and PAX5 (显示 PAX5 抗体)) that are strongly correlated to, and can have a predictive value for the clinical outcome of oral squamous cell carcinoma patients

  10. In Lynch syndrome families, prostate cancer was associated with mutations in MSH6 with loss of the mismatch repair protein (显示 MSH2 抗体).

Mouse (Murine) MutS Homolog 6 (E. Coli) (MSH6) interaction partners

  1. we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions

  2. Data suggest that MSH6 protects B cells from neoplastic transformation by preserving genomic stability.

  3. similar defects on switching in Msh2 (显示 MSH2 抗体)(-/-), Msh2 (显示 MSH2 抗体)(-/-)Msh6(-/-) and Msh2 (显示 MSH2 抗体)(-/-)Msh6(-/-)Msh3 (显示 MSH3 抗体)(-/-) mice confirm that MutSalpha but not MutSbeta plays an important role in class switch recombination

  4. Msh6 deficiency resulted in somatic instability of a (GTG (显示 GGT1 抗体))84 repeat.

  5. role for Msh6 in protective cellular responses of primary cells to ultraviolet-B-induced mutagenesis and, hence, the prevention of skin cancer.

  6. Data suggest that MutS homologues Msh2 (显示 MSH2 抗体), Msh3 (显示 MSH3 抗体), and Msh6 play overlapping and distinct roles during antibody diversification processes.

  7. Data suggest that activation-induced cytidine deaminase (显示 AICDA 抗体) has limited entry points into V and S regions in vivo, and subsequent mutation requires Msh2 (显示 MSH2 抗体)-Msh6, but not Msh3 (显示 MSH3 抗体), and DNA polymerase (显示 POLB 抗体).

  8. Mice nullizygous for both Msh2 (显示 MSH2 抗体) and Msh3 (显示 MSH3 抗体) and those nullizygous for both Msh3 (显示 MSH3 抗体) and Msh6 displayed the greatest overall increases in mutation frequencies compared with wild-type mice.

  9. in Msh6(-/-)Ung (显示 UNG 抗体)(-/-) mice, mutations were mostly C,G transitions and class switch recombination was greatly reduced.

  10. p53 (显示 TP53 抗体) and Msh6 are functionally interrelated and these tumor suppressors act together to accelerate tumorigenesis.

MSH6 抗原简介

Antigen Summary

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Alternative names and synonyms associated with MSH6

  • mutS homolog 6 (E. coli) (LOC100360342) 抗体
  • mutS homolog 6 (E. coli) (msh6) 抗体
  • mutS homolog 6 (E. coli) (Msh6) 抗体
  • mutS homolog 6 (E. coli) (MSH6) 抗体
  • mutS homolog 6 (E. coli) (LOC100227810) 抗体
  • AU044881 抗体
  • AW550279 抗体
  • cb326 抗体
  • GTBP 抗体
  • Gtmbp 抗体
  • HNPCC5 抗体
  • HSAP 抗体
  • LOC100227810 抗体
  • p160 抗体
  • wu:fb36c12 抗体

Protein level used designations for MSH6

rCG61559-like , DNA mismatch repair protein Msh6 , mutS homolog 6 (E. coli) , DNA mismatch repair protein Msh6-like , G/T mismatch-binding protein , mutS-alpha 160 kDa subunit , sperm-associated protein , g/T mismatch-binding protein , p160

GENE ID SPECIES
100360342 Rattus norvegicus
260437 Danio rerio
366547 Rattus norvegicus
421291 Gallus gallus
459218 Pan troglodytes
100033356 Monodelphis domestica
100227810 Taeniopygia guttata
100351645 Oryctolagus cuniculus
100458732 Pongo abelii
100471984 Ailuropoda melanoleuca
100541959 Meleagris gallopavo
100562407 Anolis carolinensis
100593553 Nomascus leucogenys
2956 Homo sapiens
474585 Canis lupus familiaris
17688 Mus musculus
540526 Bos taurus
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