This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
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Soloaga, Thomson, Wiggin, Rampersaud, Dyson, Hazzalin, Mahadevan, Arthur: "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14." in: The EMBO journal, Vol. 22, Issue 11, pp. 2788-97, (2003) (PubMed).
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