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- 抗原 See all MSK2 (RPS6KA4) 抗体
- MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))
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抗原表位
- Thr568
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MSK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized non-phosphopeptide derived from Human MSK2 around the phosphorylation site of threonine 568 (M-Q-T(p)-P-C).
- 亚型
- IgG
- Top Product
- Discover our top product RPS6KA4 Primary Antibody
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anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 237-393) antibody
RPS6KA4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (C-Term) antibodyRPS6KA4 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (pThr568) antibodyRPS6KA4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 1-220) antibodyRPS6KA4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 322-354) antibodyRPS6KA4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (pThr568) antibodyRPS6KA4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (Internal Region) antibodyRPS6KA4 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (C-Term) antibodyRPS6KA4 适用: 人, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 322-354), (C-Term) antibodyRPS6KA4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB1020 unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 531-580), (pThr568) antibodyRPS6KA4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))
- 别名
- RPS6KA4 (RPS6KA4 产品)
- 别名
- MSK2 antibody, RSK-B antibody, 1110069D02Rik antibody, 90kDa antibody, AI848992 antibody, Msk2 antibody, mMSK2 antibody, ribosomal protein S6 kinase A4 antibody, ribosomal protein S6 kinase, polypeptide 4 antibody, RPS6KA4 antibody, Rps6ka4 antibody
- 背景
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Background: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Pierrat B.,J. Biol. Chem. 273:29661-29671(1998).
Deak M.,EMBO J. 17:4426-4441(1998).
Soloaga A.,EMBO J. 22:2788-2797(2003).
Aliases: 90 kDa ribosomal protein S6 kinase 4 antibody, EC 2.7.11.1 antibody, KS6A4_HUMAN antibody, Mitogen and stress activated protein kinase 2 antibody, Nuclear mitogen and stress activated protein kinase 2 antibody, Nuclear mitogen- and stress-activated protein kinase 2 antibody, Ribosomal protein kinase B antibody, Ribosomal protein S6 kinase 90kD polypeptide 4 antibody, Ribosomal protein S6 kinase 90 kDa polypeptide 4 antibody, Ribosomal protein S6 kinase alpha 4 antibody, Ribosomal protein S6 kinase alpha-4 antibody, RPS6KA4 antibody, RSKB antibody, S6K-alpha-4 antibody
- UniProt
- O75676
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