anti-Topoisomerase II alpha (TOP2A) 抗体产品概述

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anti-Topoisomerase (DNA) II alpha 170kDa 抗体 (TOP2A)
在www.antibodies-online.cn可供267 Topoisomerase (DNA) II alpha 170kDa (TOP2A) 抗体的22不同的供货商。 再加上,我们可以发Topoisomerase II alpha 试剂盒 (23)Topoisomerase II alpha 蛋白 (3)和数多这个蛋白质的别的产品。 总共295 Topoisomerase II alpha产品已列进来了。
别名:
D230016L12Rik, TOP-2, TOP2, TOP2A, TP2A

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引用最多的anti-Topoisomerase II alpha 抗体

  1. Human Monoclonal Topoisomerase II alpha Primary Antibody for WB - ABIN1109282 : Yoshida, Yamaguchi, Shinagawa, Taira, Nakayama, Miki: Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. in Molecular and cellular biology 2006 (PubMed)
    Show all 8 references for 1109282

  2. Human Monoclonal Topoisomerase II alpha Primary Antibody for IHC (p), IP - ABIN1109281 : Kaplan, Greenlund, Tanner, Shaw, Schreiber: Identification of an interferon-gamma receptor alpha chain sequence required for JAK-1 binding. in The Journal of biological chemistry 1996 (PubMed)
    Show all 7 references for 1109281

  3. Human Polyclonal Topoisomerase II alpha Primary Antibody for EIA, WB - ABIN955291 : Vranic, Frkovic-Grazio, Lamovec, Serdarevic, Gurjeva, Palazzo, Bilalovic, Lee, Gatalica: Adenoid cystic carcinomas of the breast have low Topo IIα expression but frequently overexpress EGFR protein without EGFR gene amplification. in Human pathology 2010 (PubMed)
    Show all 5 references for 955291

  4. Human Polyclonal Topoisomerase II alpha Primary Antibody for ELISA, WB - ABIN1533131 : Lang, Mirski, Cummings, Yu, Gerlach, Cole: Structural organization of the human TOP2A and TOP2B genes. in Gene 1998 (PubMed)

  5. Human Polyclonal Topoisomerase II alpha Primary Antibody for EIA, IF - ABIN955290 : Kawamura, Pope, Christensen, Sun, Terekhova, Boege, Mielke, Andersen, Marko: Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements. in The Journal of cell biology 2010 (PubMed)

更多抗Topoisomerase II alpha的相互作用对抗体

Mouse (Murine) Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (显示 TOP2 抗体)-targeting agents.

  2. We demonstrated that Nup98 (显示 NUP98 抗体)-TopIIbeta and Nup98 (显示 NUP98 抗体)-SETBP1 (显示 SETBP1 抗体) negatively regulate the XPO1 (显示 XPO1 抗体)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (显示 NUP98 抗体)-fusion proteins induce tumorigenesis.

  3. TOP2 (显示 TOP2 抗体) and BAF (显示 BANF1 抗体) cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF (显示 BANF1 抗体) complexes.

  4. Deletion or deficiency of PTEN (显示 PTEN 抗体) leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.

  5. Inhibition of DNA topoisomerase II (显示 TOP2 抗体) selectively reduces the threat of tumorigenicity

  6. Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II.

  7. Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug.

  8. TOP2beta (显示 TOP2B 抗体) as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  9. Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation.

  10. studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF (显示 BANF1 抗体) complexes and suggest that this activity contributes to the role of BAF (显示 BANF1 抗体) subunits as tumour suppressors

Human Topoisomerase (DNA) II alpha 170kDa (TOP2A) interaction partners

  1. Tumors with higher topoisomerase IIalpha and/or mitosin (显示 CENPF 抗体) expression have a higher risk of recurrence after initial treatment, and these patients may benefit from adjuvant treatment and closer radiological follow-up

  2. Both the genome instability and cell death of MRE11 (显示 MRE11A 抗体)-null and MRE11 (显示 MRE11A 抗体)-mutated H129N cells are significantly reversed by overexpression of Tdp2 (显示 TDP2 抗体), an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 (显示 MRE11A 抗体) nuclease (显示 DCLRE1C 抗体) activity is likely to remove the DNA lesions.

  3. we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (显示 TCF4 抗体) and interacts with Wnt (显示 WNT2 抗体) response elements (WREs) and promoters of direct target genes of TCF (显示 HNF4A 抗体) transcription, including: MYC (显示 MYC 抗体), vimentin (显示 VIM 抗体), AXIN2 (显示 AXIN2 抗体) and LEF1 (显示 LEF1 抗体)

  4. This study shows that both survivin (显示 BIRC5 抗体) and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (显示 IDH1 抗体)-mutation status

  5. Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (显示 TOP2 抗体)-targeting agents.

  6. BD ProExtrade mark C assay containing MCM2 (显示 MCM2 抗体) and TOP2A antibodies showed strong specific nuclear staining that correlated with increased cervical dysplasia and lesion severity.

  7. Fbxo28 (显示 FBXO28 抗体) regulates topoisomerase IIalpha decatenation activity and plays an important role in maintaining genomic stability.

  8. TOP2A rs471692 was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer.

  9. we propose that phosphorylation of TOP2A by CDC7 (显示 CDC7 抗体)/DBF4 (显示 DBF4 抗体) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A function could be relevant to prevent premature separation of centromeric DNA.

  10. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II (显示 TOP2 抗体) positivity were strong predictors for preoperative epileptic seizures.

Topoisomerase II alpha (TOP2A) 抗原简介

Antigen Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Alternative names and synonyms associated with Topoisomerase II alpha (TOP2A)

  • DNA topoisomerase II, alpha isozyme (TOP2A) 抗体
  • DNA topoisomerase II, alpha isozyme (Bm1_08705) 抗体
  • topoisomerase (DNA) II alpha (Top2a) 抗体
  • topoisomerase (DNA) II alpha 170kDa (TOP2A) 抗体
  • topoisomerase (DNA) II beta (Top2b) 抗体
  • topoisomersae II (TOPOII) 抗体
  • D230016L12Rik 抗体
  • TOP-2 抗体
  • TOP2 抗体
  • TOP2A 抗体
  • TP2A 抗体

Protein level used designations for TOP2A

DNA topoisomerase II, alpha isozyme , DNA Topoisomerase II alpha , DNA topoisomerase 2-alpha , topoisomerase (DNA) 2 alpha , DNA gyrase , DNA topoisomerase (ATP-hydrolyzing) , DNA topoisomerase II, 170 kD , DNA topoisomeraseII_alpha , DNA topoisomerase 2-beta , DNA topoisomerase II, beta isozyme

GENE ID SPECIES
700707 Macaca mulatta
6096668 Brugia malayi
21973 Mus musculus
360243 Rattus norvegicus
100689304 Cricetulus griseus
7153 Homo sapiens
480525 Canis lupus familiaris
395570 Gallus gallus
787696 Bos taurus
21974 Mus musculus
396917 Sus scrofa
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