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Topoisomerase II alpha 产品

(Topoisomerase (DNA) II alpha 170kDa (TOP2A))
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].

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Featured Topoisomerase II alpha Categories

Topoisomerase II alpha 抗体

High quality antibodies with extensive validation data.

Topoisomerase II alpha ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Topoisomerase II alpha 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Topoisomerase II alpha 抗体

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Reactivity
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Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (12)
Cat. No. ABIN7075937
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (1)
  • (5)
Cat. No. ABIN563224
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, IF, StM
Validations
  • (7)
Cat. No. ABIN6940773
Quantity 100 μg
Datasheet Datasheet

Recommended Topoisomerase II alpha ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970754
Quantity 96 tests
Datasheet Datasheet
Reactivity Pig
Analytical Method
Validations
Cat. No. ABIN1130212
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1130209
Quantity 96 tests
Datasheet Datasheet

Recommended Topoisomerase II alpha 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323347
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7013599
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2751809
Quantity 5 applications
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Latest Publications for our Topoisomerase II alpha Products

Jiang, Mohan, Endo, Shen, Wu: "Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity." in: Oncotarget, Vol. 9, Issue 5, pp. 6095-6108, (2018) (PubMed).

Poonperm, Takata, Hamano, Matsuda, Uchiyama, Hiraoka, Fukui: "Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins." in: Scientific reports, Vol. 5, pp. 11916, (2015) (PubMed).

Lindén, Segersten, Runeson, Wester, Busch, Pettersson, Lind, Malmström: "Tumour expression of bladder cancer-associated urinary proteins." in: BJU international, Vol. 112, Issue 3, pp. 407-15, (2013) (PubMed).

Andersson, Konrad, Ashok, Pontén, Hober, Asplund: "Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 61, Issue 11, pp. 773-84, (2013) (PubMed).

Mondal, Parvin: "DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates." in: Nature, Vol. 413, Issue 6854, pp. 435-8, (2001) (PubMed).

Synonyms and alternative names related to Topoisomerase II alpha

DNA topoisomerase II alpha (TOP2A), DNA topoisomerase II, alpha isozyme (Bm1_08705), topoisomerase (DNA) II alpha (Top2a), DNA topoisomerase II alpha (Top2a), topoisomerase (DNA) II alpha (TOP2A), Zincin-like metalloproteases family protein (AT5G10540), DNA topoisomerase II alpha (top2a), F12B17.110, F12B17_110, fc08c07, thimet metalloendopeptidase 2, Top-2, TOP-2, TOP2, TOP2A, TP2A, wu:fc08c07

Protein level used designations for Topoisomerase II alpha

  • DNA gyrase
  • DNA topoisomerase (ATP-hydrolyzing)
  • DNA topoisomerase 2-alpha
  • DNA topoisomerase II, 170 kD
  • DNA topoisomerase II, alpha isozyme
  • DNA Topoisomerase II alpha
  • topoisomerase (DNA) 2 alpha
  • DNA topoisomeraseII_alpha
  • topoisomerase (DNA) II alpha
  • Thimet metalloendopeptidase 2
  • Zincin-like metalloproteases family protein 2
  • topoisomerase 2
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