anti-APP (APP) 抗体产品概述

Full name:
anti-Amyloid beta (A4) Precursor Protein 抗体 (APP)
在www.antibodies-online.cn可供915 Amyloid beta (A4) Precursor Protein (APP) 抗体的41不同的供货商。 再加上,我们可以发APP 试剂盒 (107)APP 蛋白 (46)和数多这个蛋白质的别的产品。 总共1103 APP产品已列进来了。
别名:
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740

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引用最多的anti-APP 抗体

  1. Human Polyclonal APP Primary Antibody for EIA, WB - ABIN358081 : Borroni, Colciaghi, Caltagirone, Rozzini, Broglio, Cattabeni, Di Luca, Padovani: Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study. in Archives of neurology 2003 (PubMed)
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  2. Human Polyclonal APP Primary Antibody for WB - ABIN389515 : Lleó, Berezovska, Ramdya, Fukumoto, Raju, Shah, Hyman: Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for 389515

  3. Human Polyclonal APP Primary Antibody for EIA, WB - ABIN358841 : Zhou, Su, Li, Liu, Ryder, Wu, Gonzalez-DeWhitt, Gelfanova, Hale, May, Paul, Ni: Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. in Science (New York, N.Y.) 2003 (PubMed)
    Show all 5 references for 358841

  4. Human Polyclonal APP Primary Antibody for IF, WB - ABIN197432 : Eng, Lund, Campenot: Synthesis of beta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 (PubMed)
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  5. Human Polyclonal APP Primary Antibody for WB - ABIN652995 : Chen, Fernandez: Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein. in Biochemical and biophysical research communications 2005 (PubMed)
    Show all 3 references for 652995

  6. Human Monoclonal APP Primary Antibody for WB - ABIN1449275 : Gylys, Fein, Yang, Wiley, Miller, Cole: Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. in The American journal of pathology 2004 (PubMed)
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  7. Human Polyclonal APP Primary Antibody for IF, IHC (p) - ABIN657612 : Singh, Park, Bae, Yun, Bae, Park, Kim: MEGF10 functions as a receptor for the uptake of amyloid-β. in FEBS letters 2010 (PubMed)
    Show all 2 references for 657612

  8. Cow (Bovine) Polyclonal APP Primary Antibody for WB - ABIN2777738 : Locascio, Fukumoto, Yap, Bottiglieri, Growdon, Hyman, Irizarry: Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. in Archives of neurology 2008 (PubMed)

更多抗APP的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (显示 GRIN2A 抗体) recycling.

  2. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  3. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  4. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  5. APPL is the first example of a modulator of the Wnt (显示 WNT4 抗体)-PCP (显示 PRCP 抗体) pathway specifically required for axon outgrowth.

  6. Data show that Appl is directly regulated by the Ras/MAPK (显示 MAPK1 抗体) pathway through a mechanism mediated by PntP2 (显示 ETS2 抗体).

  7. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  8. Disruption of amyloid protein (显示 IAPP 抗体) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  9. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (显示 ABCA2 抗体)) reduces amyloid-beta production by altering Nicastrin (显示 NCSTN 抗体) maturation and intracellular localization.

  10. accumulation of Ass42 plaques induces JNK (显示 MAPK8 抗体) signaling in neurons and induction of JNK (显示 MAPK8 抗体) contributes to Ass42 mediated cell death

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein, Presenilin 1 (显示 PSEN1 抗体), and Presenilin 2 (显示 PSEN2 抗体) as a cause of autosomal dominant AD

  2. The authors now show that the very little Abeta generated by PS1 (显示 PSEN1 抗体) L435F mutant consists primarily of Abeta43, a highly amyloidogenic species which was overlooked in previous studies of this mutant.

  3. Complicated function of dopamine in Abeta-related neurotoxicity: Dual interactions with Tyr (显示 TYR 抗体)(10) and SNK(26-28) of Abeta

  4. These studies support the hypothesis that the ratio of Abeta monomers to Abeta oligomers is a critical factor that regulates synapse damage.

  5. UBQLN4 (显示 UBQLN4 抗体), APP, CTNNB1 (显示 CTNNB1 抗体), SHBG (显示 SHBG 抗体), and COL1A1 (显示 COL1A1 抗体) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition

  6. Fe65 (显示 APBB1 抗体) is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-beta precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 (显示 APBB1 抗体) constructs expressed in human neuroblastoma (显示 ARHGEF16 抗体) cells. Our results indicate that PTB2 (显示 PTBP1 抗体) rather than the WW domain (显示 DRP2 抗体) is important for the nuclear localization of Fe65 (显示 APBB1 抗体).

  7. bis (显示 BAG3 抗体)(sulfosuccinimidyl) suberate (BS3) was used to cross-link Abeta1-42 oligomers prior to electrophoresis. When compared to a previously reported Abeta cross-linking agent, glutaraldehyde, it was quite apparent that BS3 is more suitable for detecting intra-membrane Abeta oligomers and extra-membrane Abeta oligomers states.

  8. This is the first report to show decreased Amyloid beta levels in plasma in Amyloid beta Precursor Protein A673T carriers and thus provides evidence that lower Abeta levels throughout life may be protective against Alzheimer Disease.

  9. APP + PS1 (显示 PSEN1 抗体) double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP + PS1 (显示 PSEN1 抗体) rats showed brain pathology as well as reduced memory retention compared to the APP and the ...

  10. common in cognitively normal older adults. However, evidence of pathological effects on episodic memory has largely been limited to beta-amyloid (Abeta). Because Abeta and tau often cooccur in older adults, previous research offers an incomplete understanding of the relationship between pathology and episodic memory.

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (显示 CD36 抗体)- and CD47 (显示 CD47 抗体)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (显示 APOE 抗体) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. APP and its metabolites are capable of influencing the basic physiology of the pancreas.

  2. treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4

  3. These results provide evidence supporting a key role for the p38 MAPK (显示 MAPK14 抗体) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 (显示 LRP1 抗体) in vivo.

  4. increased APP and/or beta-CTF impact the endocytic pathway to disrupt NGF trafficking and signaling, resulting in trophic deficits in basal forebrain cholinergic neurons.

  5. ABETA 25-35 downregulated miR (显示 MLXIP 抗体)-137 and upregulated TNFAIP1 (显示 TNFAIP1 抗体) in cortical neurons and N2a cells.

  6. These results indicate that platelet APP limits venous thromboembolism through a negative regulation of both fibrin formation and neutrophil function.

  7. These findings highlight for the first time that APP-dependent glial cell line-derived neurotropic factor expression drives the process of neuromuscular junction formation, providing new insights into the link between APP gene regulatory network and physiologic functions.

  8. TREM2 (显示 TREM2 抗体) protects from Alzheimer's disease by enabling microglia to surround and alter Abeta plaque structure, thereby limiting neuritic damage.

  9. To conclude, our data corroborate a major role of APP for structural plasticity and adaptive remodeling of cortical synapses in the adult brain. They also indicate that lack of APP holoprotein leads to impaired D-serine homeostasis, which is associated with dysfunctional synaptic plasticity.

  10. Pretreatment with a P-glycoprotein inhibitor, which blocks blood-brain barrier transport of Abeta, resulted in significant prolongation of Abeta40 half-life, but only in the latter phase of Abeta clearance from the interstitial fluid.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (显示 S100A8 抗体)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (显示 PRNP 抗体) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (显示 MKRN1 抗体) and Aplp2 (显示 APLP2 抗体) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (显示 PSEN1 抗体)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (显示 SUCLA2 抗体) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (显示 IGF1 抗体) signaling

APP 抗原简介

Antigen Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl) 抗体
  • amyloid beta (A4) precursor protein (APP) 抗体
  • amyloid beta (A4) precursor protein (app) 抗体
  • amyloid beta (A4) precursor protein (App) 抗体
  • amyloid beta (A4) precursor protein a (appa) 抗体
  • beta amyloid protein precursor (LOC100009546) 抗体
  • AAA 抗体
  • ABETA 抗体
  • Abpp 抗体
  • AD1 抗体
  • Adap 抗体
  • Ag 抗体
  • app 抗体
  • APP-like 抗体
  • APPI 抗体
  • appl 抗体
  • BcDNA:GH04413 抗体
  • betaApp 抗体
  • CG7727 抗体
  • CTFgamma 抗体
  • Cvap 抗体
  • Dmel\\CG7727 抗体
  • E030013M08Rik 抗体
  • EG:65F1.5 抗体
  • PN-II 抗体
  • PN2 抗体
  • wu:fj34d10 抗体
  • wu:fk65e12 抗体
  • zgc:85740 抗体

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

GENE ID SPECIES
31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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