JAK1 抗体 (AA 551-766)
(4 references)-
- 抗原 See all JAK1 抗体
- JAK1 (Janus Kinase 1 (JAK1))
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抗原表位
- AA 551-766
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适用
- 人, 小鼠, 大鼠, 小鸡, 犬, Frog
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This JAK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- 交叉反应
- 犬, 大鼠, 小鼠, 小鸡, Frog
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human JAK1 aa. 551-766
- 克隆位点
- 73-JAK1
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product JAK1 Primary Antibody
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anti-Janus Kinase 1 (JAK1) (pTyr1022), (pTyr1023) antibody
JAK1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 120-380) antibodyJAK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) antibodyJAK1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Janus Kinase 1 (JAK1) (pTyr1022) antibodyJAK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 960-1040) antibodyJAK1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 1020-1024) antibodyJAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Janus Kinase 1 (JAK1) (AA 866-899), (C-Term) antibodyJAK1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB43812 unconjugated
anti-Janus Kinase 1 (JAK1) antibodyJAK1 适用: 人, 大鼠 WB, IP 宿主: 小鼠 Monoclonal 7B1-B6-G7 unconjugated
anti-Janus Kinase 1 (JAK1) (AA 172-204), (N-Term) antibodyJAK1 适用: 人 WB 宿主: 兔 Polyclonal RB43809 unconjugated
anti-Janus Kinase 1 (JAK1) antibodyJAK1 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 小鼠 Monoclonal 7G6 unconjugated
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." in: Oncogene, Vol. 21, Issue 44, pp. 6791-800, (2002) (PubMed).
: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, (2001) (PubMed).
: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." in: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, (2001) (PubMed).
: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." in: Nature, Vol. 366, Issue 6451, pp. 129-35, (1993) (PubMed).
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: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." in: Oncogene, Vol. 21, Issue 44, pp. 6791-800, (2002) (PubMed).
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- 抗原
- JAK1 (Janus Kinase 1 (JAK1))
- 别名
- JAK1 (JAK1 产品)
- 别名
- JAK1A antibody, JAK1B antibody, JTK3 antibody, AA960307 antibody, C130039L05Rik antibody, wu:fb93e10 antibody, jak1 antibody, Janus kinase 1 antibody, tyrosine-protein kinase JAK1 antibody, JAK1 antibody, Jak1 antibody, jak1 antibody, LOC100286690 antibody
- 背景
- The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.
- 分子量
- 130 kDa
- 途径
- JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response
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