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MSH2 抗体

MSH2 适用: 人 WB, ELISA, IHC Monoclonal unconjugated
产品编号 ABIN966594
发货至: 中国
  • 抗原 See all MSH2 抗体
    MSH2 (Mismatch Repair Protein 2 (MSH2))
    适用
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    克隆类型
    • 72
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    单克隆
    标记
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    This MSH2 antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    特异性
    Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3).
    纯化方法
    Antibodies are purified by protein G affinity chromatography.
    亚型
    IgG1
    Top Product
    Discover our top product MSH2 Primary Antibody
  • 应用备注
    Western Blot: Dilution 1: 200- 1: 1,000
    IHC(P): Dilution 1: 200- 1: 1,000
    IHC(F): Dilution 1: 200- 1: 1,000
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 储存条件
    -20 °C
  • 抗原
    MSH2 (Mismatch Repair Protein 2 (MSH2))
    别名
    MSH2 (MSH2 产品)
    别名
    COCA1 antibody, FCC1 antibody, HNPCC antibody, HNPCC1 antibody, LCFS2 antibody, AI788990 antibody, wu:fc06b02 antibody, wu:fc13e09 antibody, zgc:55333 antibody, ATMSH2 antibody, MUTS homolog 2 antibody, msh2 antibody, mutS homolog 2 antibody, mutS homolog 2 (E. coli) antibody, MUTS homolog 2 antibody, mutS homolog 2 L homeolog antibody, MutS protein homolog 2 antibody, MSH2 antibody, Msh2 antibody, msh2 antibody, msh2.L antibody
    背景
    MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
    基因ID
    4436
    途径
    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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