(3 references)-
- 抗原 See all BTK 抗体
- BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
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适用
- 人
- 宿主
- 请咨询
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克隆类型
- 单克隆
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标记
- This BTK antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- Ni-NTA purified truncated recombinant BTK expressed in E. Coli strain BL21 (DE3)
- 纯化方法
- Crude ascites.
- 亚型
- IgG1
- Top Product
- Discover our top product BTK Primary Antibody
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anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 30-240) antibody
BTK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) antibodyBTK 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 27-55) antibodyBTK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 209-239) antibodyBTK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (pSer180) antibodyBTK 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 254-443) antibodyBTK 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (Internal Region) antibodyBTK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 206-351) antibodyBTK 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) (AA 91-387) antibodyBTK 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bruton Agammaglobulinemia tyrosine Kinase (BTK) antibodyBTK 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 7F12H4 unconjugated
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- 应用备注
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Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. - 限制
- 仅限研究用
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- 状态
- Liquid
- 储存条件
- -20 °C
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: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." in: Oncogene, Vol. 9, Issue 12, pp. 3683-8, (1994) (PubMed).
: "Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells." in: Biochemical and biophysical research communications, Vol. 192, Issue 1, pp. 231-40, (1993) (PubMed).
: "Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes." in: Science (New York, N.Y.), Vol. 261, Issue 5119, pp. 355-8, (1993) (PubMed).
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: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." in: Oncogene, Vol. 9, Issue 12, pp. 3683-8, (1994) (PubMed).
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- 抗原
- BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
- 别名
- BTK (BTK 产品)
- 别名
- BTK antibody, atk antibody, bpk antibody, xla antibody, imd1 antibody, agmx1 antibody, psctk1 antibody, AGMX1 antibody, AT antibody, ATK antibody, BPK antibody, IMD1 antibody, PSCTK1 antibody, XLA antibody, AI528679 antibody, xid antibody, Bruton tyrosine kinase antibody, Bruton agammaglobulinemia tyrosine kinase antibody, BTK antibody, btk antibody, Btk antibody
- 背景
- Brutons tyrosine kinase (BTK) is a member of the BTK/ Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.
- 基因ID
- 695
- 途径
- Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
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