The antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.
纯化方法
Affinity purified
免疫原
Peptide sequence around phosphorylation site of pTyr690 (R-K-Y (p) -L-K) derived from Human Stat2 Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.