Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) 抗体

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抗原
  • erk1/2
  • mitogen-activated protein kinase
  • erk1/2
抗原表位
pThr202, pTyr204, AA 196-210
114
103
30
30
28
19
18
17
15
15
15
15
14
12
9
9
9
8
7
7
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠, 牛
403
312
300
56
24
15
9
8
8
8
7
6
5
5
3
3
2
2
2
1
1
1
1
宿主

331
76
6
克隆类型
多克隆
标记
非结合性
12
11
11
9
7
7
7
6
6
6
6
6
6
6
2
2
2
1
1
1
1
1
1
应用范围
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
291
106
81
77
60
54
39
38
14
10
6
4
3
2
2
2
2
Supplier
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免疫原 KLH conjugated synthetic phosphopeptide derived from human p44/42 MAPK around the phosphorylation site of (Thr202/Tyr204)
亚型 IgG
纯化方法 Purified by Protein A.
别名 Erk1/2 (MAPK1/3 Antibody 摘要)
Sub Type Cocktail
背景

p44/42 MAP Kinase(Thr202), ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.

Subcellular location: Cytoplasm, Nucleus

Synonyms: ERK1, ERT2, ERK-1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, p44-ERK1, p44-MAPK, Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, Microtubule-associated protein 2 kinase, MAPK3

基因ID 5595
UniProt P27361
应用备注 WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20°C
有效期 12 months
厂商提供的图像
SDS-PAGE (SDS) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) 抗体 (ABIN682933) Lane 1: human colon carcinoma lysates probed with Anti phospho-ERK1/2(Thr202 + Tyr204...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) 抗体 (ABIN682933) Formalin-fixed and paraffin embedded human liver labeled with Anti-phospho-ERK1/2(Thr...
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) 抗体 (ABIN682933) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-phospho-E...
有引用在: Wang, Chen, Tang, Jiang, Ji: "AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 74, Issue 5, pp. 927.e1-927.e13, 2016 (PubMed).

Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, 2016 (PubMed).

Liu, Huang, Wang, Song, Cen, Ji: "Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway." in: Chemico-biological interactions, Vol. 262, pp. 1-11, 2016 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)).

Geng, Zhu, Xie, Li, Wu, Liang, Xie, Zhu, Huang, Zhu, Wu, Zhong: "Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice." in: European journal of nutrition, 2015 (PubMed).

Chen, Bao, Chen, Burton, Gong, Gu, Mi, Bao: "Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses." in: Medical microbiology and immunology, 2015 (PubMed).

Rosenzweig, Ou, Quinn: "P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture." in: Journal of cellular and molecular medicine, Vol. 17, Issue 4, pp. 508-17, 2013 (PubMed).