L-Selectin 抗体 (Selectin L)

Details for Product anti-SELL Antibody No. ABIN457418, 供应商: Log in to see
抗原
  • CD62L
  • LAM1
  • LECAM1
  • LEU8
  • LNHR
  • LSEL
  • LYAM1
  • PLNHR
  • TQ1
  • A.11
  • L-selectin
  • LECAM-1
  • SELE
  • AI528707
  • Lnhr
  • Ly-22
  • Ly-m22
  • Lyam-1
  • Lyam1
  • selectin L
  • selectin, lymphocyte
  • SELL
  • Sell
适用

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宿主
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克隆类型 (克隆位点)
单克隆 ()
标记
This L-Selectin antibody is un-conjugated
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应用范围
Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunoprecipitation (IP), Western Blotting (WB)
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选项
Supplier
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Supplier Product No.
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免疫原 PMA-activated human peripheral blood leukocytes
克隆位点 DREG56
亚型 IgG1
特异性 The mouse monoclonal antibody DREG56 recognizes CD62L / L-selectin, a 65-76 kDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells.
HLDA V, WS Code S056
纯化方法 Purified from cell culture supernatant by protein-A affinity chromatography.
纯度 > 95 % (by SDS-PAGE)
别名 SELL (SELL Antibody 摘要)
背景 CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1). The level of CD62L expression can be used to help distinguish naive T cells from effector/memory T cells.
研究领域 Surface Receptors of Immune Cells, CD Antigens
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 1 mg/mL
缓冲液 Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
注意事项 Do not freeze.
储存条件 4 °C
储存方法 Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
有引用在: Tu, Mao, Zheng, Liu, Chiu, Qin, Chan, Lam, Guan, Zhang, Guan, Yuen, Peiris, Lau: "Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus." in: Journal of virology, Vol. 84, Issue 13, pp. 6527-35, 2010 (PubMed).

Killock, Parsons, Zarrouk, Ameer-Beg, Ridley, Haskard, Zvelebil, Ivetic: "In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin." in: The Journal of biological chemistry, Vol. 284, Issue 13, pp. 8833-45, 2009 (PubMed).

Xu, Chen, Shang, Cui, Luo, Chen, Ba, Zeng: "Critical role of Lck in L-selectin signaling induced by sulfatides engagement." in: Journal of leukocyte biology, Vol. 84, Issue 4, pp. 1192-201, 2008 (PubMed).

Jutila, Kurk, Jackiw, Knibbs, Stoolman: "L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 4, pp. 1768-73, 2002 (PubMed).

Kishimoto, Warnock, Jutila, Butcher, Lane, Anderson, Smith: "Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro." in: Blood, Vol. 78, Issue 3, pp. 805-11, 1991 (PubMed).

Kishimoto, Jutila, Butcher: "Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 6, pp. 2244-8, 1990 (PubMed).

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