L-Selectin 抗体 (Selectin L)

Details for Product anti-SELL Antibody No. ABIN457405, 供应商: Log in to see
抗原
  • CD62L
  • LAM1
  • LECAM1
  • LEU8
  • LNHR
  • LSEL
  • LYAM1
  • PLNHR
  • TQ1
  • A.11
  • L-selectin
  • LECAM-1
  • SELE
  • AI528707
  • Lnhr
  • Ly-22
  • Ly-m22
  • Lyam-1
  • Lyam1
  • selectin L
  • selectin, lymphocyte
  • SELL
  • Sell
适用
小鼠
633
41
38
14
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1
宿主
大鼠
352
257
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13
2
1
1
克隆类型 (克隆位点)
单克隆 ()
标记
This L-Selectin antibody is un-conjugated
90
79
43
41
18
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16
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14
12
9
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1
应用范围
Flow Cytometry (FACS), Functional Studies (Func), Immunocytochemistry (ICC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
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1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 C3H/eb mouse B cell lymphoma 38C-13
克隆位点 MEL-14
亚型 IgG2a
特异性 The rat monoclonal antibody MEL-14 reacts with mouse CD62L (L-selectin), a 75 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes, it is also present on a subset of NK cells and certain hematopoietic malignant cells.
纯化方法 Purified by protein G
纯度 > 95 % (by SDS-PAGE)
过滤 0.2 μm filtered
内毒素水平 Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
别名 SELL (SELL Antibody 摘要)
背景 CD62L (L-selectin) is an adhesion glycoprotein that is constitutively expressed on the cell surface of leukocytes and mediates their homing to inflammatory sites and peripheral lymph nodes by enabling rolling along the venular wall. CD62L is also involved in activation-induced neutrophil aggregation. Activation-dependent CD62L shedding, however, counteracts neutrophil rolling. CD62L has also signaling roles including enhance of chemokine receptor expression. Similarly to CD62P, the major ligand of CD62L is PSGL-1 (P-selectin glycoprotein ligand-1).
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 1 mg/mL
缓冲液 Azide free phosphate buffered saline (PBS), approx. pH 7.4.
注意事项 Do not freeze.
储存条件 4 °C
储存方法 Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
有引用在: Xu, Manivannan, Crane, Dawson, Liversidge: "Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation." in: Blood, Vol. 112, Issue 4, pp. 1166-74, 2008 (PubMed).

Pop, Wong, He, Wang, Wallet, Goudy, Tisch: "The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice." in: Diabetes, Vol. 56, Issue 5, pp. 1395-402, 2007 (PubMed).

Richards, Longhi, Wright, Gallimore, Ager: "CD62L (L-selectin) down-regulation does not affect memory T cell distribution but failure to shed compromises anti-viral immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 1, pp. 198-206, 2007 (PubMed).

Chen, Cui, Sempowski, Liu, Chao: "Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease." in: Blood, Vol. 103, Issue 4, pp. 1534-41, 2004 (PubMed).

Chin, Miller, Graham, Parviz, Zacur, Patel, Duong, Bear: "Bryostatin 1/ionomycin (B/I) ex vivo stimulation preferentially activates L-selectinlow tumor-sensitized lymphocytes." in: International immunology, Vol. 16, Issue 9, pp. 1283-94, 2004 (PubMed).

Friedline, Wong, Steeber, Tedder, Tisch: "L-selectin is not required for T cell-mediated autoimmune diabetes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 6, pp. 2659-66, 2002 (PubMed).

Mannering, Cheers: "Interleukin-2 and loss of immunity in experimental Mycobacterium avium infection." in: Infection and immunity, Vol. 70, Issue 1, pp. 27-35, 2001 (PubMed).

ten Bruggencate, Hillyer, Woodward: "The proportion of CD45RA(+)CD62L(+) (quiescent-phenotype) T cells within the CD8(+) subset increases in advanced weight loss in the protein- or energy-deficient weanling mouse." in: The Journal of nutrition, Vol. 131, Issue 12, pp. 3266-9, 2001 (PubMed).

Brawand, Cerottini, MacDonald: "Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo." in: Journal of virology, Vol. 73, Issue 11, pp. 9161-9, 1999 (PubMed).

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