Axin 抗体 (C-Term)
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- 抗原 See all Axin (AXIN1) 抗体
- Axin (AXIN1) (Axin 1 (AXIN1))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This Axin antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 序列
- c-FEEKIIGKVE KVD
- 特异性
- This antibody recognizes Axin 1 (AXIN1).
- 交叉反应 （详细）
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Species reactivity (expected):Canine (Dog), Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Immunoaffinity Chromatography.
- 免疫原
- Synthetic peptide from C-terminus of Human AXIN1.
- 亚型
- IgG
- Top Product
- Discover our top product AXIN1 Primary Antibody
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anti-Axin 1 (AXIN1) (AA 546-752) antibody
AXIN1 适用: 人 WB, ELISA, IHC, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 4E9F1 unconjugated
anti-Axin 1 (AXIN1) (AA 618-827) antibodyAXIN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Axin 1 (AXIN1) (AA 643-740) antibodyAXIN1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 488)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 488
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 594)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 594
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Atto 390)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Atto 390
anti-Axin 1 (AXIN1) (AA 470-570) antibody (FITC)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal FITC
anti-Axin 1 (AXIN1) (AA 470-570) antibody (Alkaline Phosphatase (AP))AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal Alkaline Phosphatase (AP)
anti-Axin 1 (AXIN1) (AA 470-570) antibody (APC)AXIN1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal APC
anti-Axin 1 (AXIN1) (AA 546-752) antibodyAXIN1 适用: 人 WB, ELISA, IHC, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 4F10G1 unconjugated
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- 应用备注
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ELISA: 1/28000. Immunohistochemistry on Paraffin Sections: 3.75 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Tris-Saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- 抗原
- Axin (AXIN1) (Axin 1 (AXIN1))
- 别名
- Axin-1 (AXIN1 产品)
- 别名
- AXIN1 antibody, axin antibody, fused antibody, xAxin antibody, LOC100226467 antibody, AXIN antibody, PPP1R49 antibody, AI316800 antibody, Axin antibody, Fu antibody, Kb antibody, Ki antibody, kinky antibody, knobbly antibody, AXIN1-RGS antibody, wu:fi22e03 antibody, wu:fj14c08 antibody, wu:fk11b03 antibody, zgc:109872 antibody, axin 1 antibody, axin 1 S homeolog antibody, axin 1 L homeolog antibody, AXIN1 antibody, axin1.S antibody, axin1.L antibody, Axin1 antibody, axin1 antibody
- 背景
- Axin-1 (Axis inhibition protein 1) and Axin-2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin-1 interacts with APC, GSK3-beta, Dvl and beta-Catenin and promotes the GSK3-beta-mediated phosphorylation and subsequent degradation of beta-Catenin (1,2). Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling (3,4). In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) (5). Axin2 (also known as Conductin or Axil) can functionally substitute Axin1 in mice (6). Axin-2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop (7-9).Synonyms: AXIN, AXIN1, Axis inhibition protein 1
- 基因ID
- 8312
- NCBI登录号
- NP_003493
- UniProt
- O15169
- 途径
- WNT signaling, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling
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