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CREB1 抗体 (pSer133)

CREB1 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 小鸡, 绵羊, 犬, 非洲爪蟾, Non-Human Primate WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN372604
发货至: 中国
  • 抗原 See all CREB1 抗体
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    抗原表位
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    pSer133
    适用
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    人, 小鼠, 大鼠, 斑马鱼, Cow, 小鸡, 绵羊, 犬, 非洲爪蟾, Non-Human Primate
    宿主
    • 264
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    克隆类型
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    多克隆
    标记
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    This CREB1 antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Specific for the ~45k CREB protein phosphorylated at Ser133. Immunolabeling is blocked by lambda-phosphatase treatment.
    交叉反应 (详细)
    Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, Sheep, Xenopus, Zebrafish and non-Human Primates.
    Species reactivity (tested):Rat.
    纯化方法
    Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
    免疫原
    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB.
    亚型
    IgG
    Top Product
    Discover our top product CREB1 Primary Antibody
  • 应用备注
    Western Blot: 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody undiluted (in aliquots) at-20 °C.
  • 抗原
    CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))
    别名
    CREB1 (CREB1 产品)
    别名
    creb antibody, CREB1 antibody, Creb1 antibody, CREB antibody, 2310001E10Rik antibody, 3526402H21Rik antibody, AV083133 antibody, Creb antibody, Creb-1 antibody, creb1 antibody, zgc:55598 antibody, cAMP responsive element binding protein 1 antibody, cAMP responsive element binding protein antibody, cAMP responsive element binding protein 1 S homeolog antibody, cAMP responsive element binding protein 1a antibody, CREB1 antibody, creb1 antibody, CREB antibody, Creb1 antibody, creb1.S antibody, creb1a antibody
    背景
    It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus (Karin and Hunter, 1995). The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors (Montminy, 1997). This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory (Shaywitz and Greenberg, 1999, Silva et al., 1998). A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 are required for CREB-mediated transcription (Johannessen et al., 2004, Kornhauser et al., 2002).Synonyms: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1
    基因ID
    81646
    NCBI登录号
    NP_112279
    UniProt
    P15337
    途径
    TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation
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