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PAK2 抗体 (P21-Activated Kinase 2) (N-Term)

Details for Product anti-PAK2 Antibody No. ABIN360318, 供应商: Log in to see
抗原
  • pak2
  • cb422
  • kinase
  • zgc:91798
  • wu:fb71h01
  • si:dz198m22.1
  • pak65
  • pakgamma
  • PAK65
  • PAKgamma
  • 5330420P17Rik
  • A130002K10Rik
  • AI836325
  • D16Ertd269e
  • PAK-2
  • mKIAA4182
  • gamma-PAK
  • PAKI
  • Pak3
  • p21 (CDKN1A)-activated kinase 2a
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • pak2a
  • pak2
  • PAK2
  • Pak2
抗原表位
N-Term
41
21
12
11
6
5
5
4
3
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
适用

185
97
92
12
8
1
宿主

166
19
克隆类型
多克隆
标记
This PAK2 antibody is un-conjugated
4
4
4
4
4
4
应用范围
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
166
101
76
35
19
6
6
4
2
2
2
1
Supplier
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免疫原 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PAK2.
亚型 Ig
特异性 This antibody reacts to PAK2.
纯化方法 Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
别名 PAK2 (PAK2 Antibody 摘要)
背景 PAK2, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. PAK2 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Expression is ubiquitous, with higher levels seen in skeletal muscle, ovary, thymus and spleen. PAK2 is autophosphorylated when activated by CDC42/p21. The protein structure contains 1 CRIB domain.Synonyms: Gamma-PAK, PAK 2, PAK gamma, PAK-2, PAK65, Serine/threonine-protein kinase PAK 2, p21-activated kinase 2, p58
基因ID 5062, 9606
UniProt Q13177
研究领域 Cancer, Apoptosis/Necrosis, Tyrosine Kinases, Kinases/Phosphatases
途径 MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
应用备注 ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
状态 Liquid
浓度 0.25 mg/mL
缓冲液 PBS with 0.09 % (W/V) sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
厂商提供的图像
 image for anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody (ABIN360318) anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody
 image for anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody (ABIN360318) anti-P21-Activated Kinase 2 (PAK2) (N-Term) antibody (Image 2)
背景 Benner, Dennis, Masaracchia: "Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 21121-8, 1995 (PubMed).

Martin, Bollag, McCormick, Abo: "A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20." in: The EMBO journal, Vol. 14, Issue 9, pp. 1970-8, 1995 (PubMed).

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