L-Selectin 抗体 (Selectin L) (PE)

Details for Product anti-SELL Antibody No. ABIN319797, 供应商: Log in to see
抗原
  • CD62L
  • LAM1
  • LECAM1
  • LEU8
  • LNHR
  • LSEL
  • LYAM1
  • PLNHR
  • TQ1
  • A.11
  • L-selectin
  • LECAM-1
  • SELE
  • AI528707
  • Lnhr
  • Ly-22
  • Ly-m22
  • Lyam-1
  • Lyam1
  • selectin L
  • selectin, lymphocyte
  • SELL
  • Sell
适用
化学剂
633
39
37
14
3
1
1
1
宿主
小鼠
347
258
93
13
2
1
1
克隆类型 (克隆位点)
单克隆 ()
标记
This L-Selectin antibody is conjugated to PE
90
78
43
41
17
17
16
16
14
12
9
8
8
8
8
8
8
6
6
6
6
6
6
6
4
4
4
4
3
2
2
2
2
1
应用范围
Flow Cytometry (FACS)
592
201
156
131
88
79
47
42
18
13
12
11
10
9
7
7
5
4
3
3
2
2
2
2
2
2
2
1
1
1
选项
Supplier
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Supplier Product No.
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免疫原 PHA stimulated lymphoblasts. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
克隆位点 FMC46
亚型 IgG2b
特异性 This antibody recognizes CD62L, also known a L-selectin.
纯化方法 Affinity chromatography on Protein G
别名 CD62L / L-Selectin (SELL Antibody 摘要)
物质类 Chemical
背景 CD62L is a 74-95? kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.Synonyms: CD62 antigen-like family member L, LAM-1, LECAM1, LNHR, LYAM1, Leu-8, Leukocyte adhesion molecule 1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, Lymph node homing receptor, SELL, TQ1, gp90-MEL
基因ID 6402
NCBI登录号 NP_000646
UniProt P14151
应用备注 Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
溶解方式 Restore with 0.25 mL distilled water.
缓冲液 PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 This product is photosensitive and should be protected from light
储存条件 4 °C
储存方法 Prior to and following reconstitution store the antibody at 2-8 °C. DO NOT FREEZE!
背景 Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

Sopp, Howard: "Cross-reactivity of monoclonal antibodies to defined human leucocyte differentiation antigens with bovine cells." in: Veterinary immunology and immunopathology, Vol. 56, Issue 1-2, pp. 11-25, 1997 (PubMed).

Zola, Macardle, Flego, Webster: "The expression of sub-population markers on B cells: a re-evaluation using high-sensitivity fluorescence flow cytometry." in: Disease markers, Vol. 9, Issue 2, pp. 103-18, 1992 (PubMed).

Pilarski, Turley, Shaw, Gallatin, Laderoute, Gillitzer, Beckman, Zola: "FMC46, a cell protrusion-associated leukocyte adhesion molecule-1 epitope on human lymphocytes and thymocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 1, pp. 136-43, 1991 (PubMed).

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