HLA-A 抗体 (Major Histocompatibility Complex, Class I, A) (Pacific Blue)

Details for Product anti-HLA-A Antibody No. ABIN2662341, 供应商: Log in to see
抗原
  • HLAA
  • major histocompatibility complex, class I, A
  • HLA-A
Alternatives
anti-人 HLA-A 抗体 for Cytometry by Time of Flight
适用

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宿主
小鼠
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克隆类型 (克隆位点)
单克隆 ()
标记
This HLA-A antibody is conjugated to Pacific Blue
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应用范围
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC)
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Supplier
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Available images

克隆位点 W6-32
亚型 IgG2a kappa
交叉反应 Chimpanzee, Baboon, Cynomolgus, 猕猴, 牛, 猫
纯化方法 The antibody was purified by affinity chromatography, and conjugated with Pacific Blue™ under optimal conditions. The solution is free of unconjugated Pacific Blue™.
别名 HLA-A (HLA-A Antibody 摘要)
背景 MHC class I antigens associated with β2-microglobulin are expressed by all human nucleated cells. MHC class I molecules are involved in presentation of antigens to CD8+ T cells. They play an important role in cell-mediated immune responses and tumor surveillance.
研究领域 Major Histocompatibility Complex (MHC), Immunology
途径 TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
浓度 0.5 mg/mL
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Protect from prolonged exposure to light. Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C.
厂商提供的图像
Flow Cytometry (FACS) image for anti-HLA-A 抗体 (Major Histocompatibility Complex, Class I, A)  (Pacific Blue) (ABIN2662341) anti-Major Histocompatibility Complex, Class I, A (HLA-A) antibody (Pacific Blue)
背景 Ayyoub, Taub, Keohan, Hesdorffer, Metthez, Memeo, Mansukhani, Hibshoosh, Hesdorffer, Valmori: "The frequent expression of cancer/testis antigens provides opportunities for immunotherapeutic targeting of sarcoma." in: Cancer immunity, Vol. 4, pp. 7, 2004 (PubMed).

Tran, Ivanyi, Hilgert, Brdicka, Pla, Breur, Flieger, Ivasková, Horejsí: "The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27/beta2-microglobulin complex." in: Immunogenetics, Vol. 53, Issue 6, pp. 440-6, 2001 (PubMed).

Fayen, Huang, Ferrone, Tykocinski: "Negative signaling by anti-HLA class I antibodies is dependent upon two triggering events." in: International immunology, Vol. 10, Issue 9, pp. 1347-58, 1998 (PubMed).

De Felice, Turco, Costanzo, Corbo, Ferrone, Venuta: "Inhibition by anti-HLA class I mAb of IL-2 and IL-2 receptor synthesis in lymphocytes stimulated with PHA-P." in: Cellular immunology, Vol. 126, Issue 2, pp. 420-7, 1990 (PubMed).

Darrow, Slingluff, Seigler: "The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 9, pp. 3329-35, 1989 (PubMed).

Geppert, Wacholtz, Patel, Lightfoot, Lipsky: "Activation of human T cell clones and Jurkat cells by cross-linking class I MHC molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 142, Issue 11, pp. 3763-72, 1989 (PubMed).

Turco, de Felice, Corbo, Giarrusso, Yang, Ferrone, Venuta: "Enhancing effect of anti-HLA class I monoclonal antibodies on T cell proliferation induced via CD2 molecule." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 141, Issue 7, pp. 2275-81, 1988 (PubMed).

Stern, Beresford, Friedman, Stevens, Risk, Johnson: "Class I-like MHC molecules expressed by baboon placental syncytiotrophoblast." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 138, Issue 4, pp. 1088-91, 1987 (PubMed).

Barbatis, Woods, Morton, Fleming, McMichael, McGee: "Immunohistochemical analysis of HLA (A, B, C) antigens in liver disease using a monoclonal antibody." in: Gut, Vol. 22, Issue 12, pp. 985-91, 1982 (PubMed).