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VEGFR2/CD309 抗体 (C-Term)

Name: VEGFR2/CD309 抗体 (C-Term)
SKU: ABIN115389
Availability: OutOfStock

VEGFR2 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated

Formalin fixed paraffin embedded human angiosarcoma stained with Flk-1 antibody

IHC

1 image

产品编号 ABIN115389

发货至: 中国

Datasheet as PDF

抗原 See all VEGFR2/CD309 (VEGFR2) 抗体

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))
抗原表位
37

36

27

22

20

16

16

15

14

10

10

8

8

6

6

6

5

5

5

4

4

3

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
302

196

145

18

9

7

4

3

3

3

2

1

1

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
303

49

9

2

1

1

1
兔
Compatible Secondaries
克隆类型
298

68
多克隆
标记
163

33

20

14

12

12

11

11

11

11

11

11

6

6

6

6

6

2

2

2

2

1

1

1

1

1

1

1

1
This VEGFR2/CD309 antibody is un-conjugated
应用范围
233

131

93

77

59

34

26

24

22

13

13

12

9

7

7

4

3

2

1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

特异性

This antibody reacts with a 180 kDa protein, known as Flk-1/KDR/Vascular endothelial growth factor receptor 2.
Cellular Localization:Cytoplasmic.

纯化方法

Purified

免疫原

A synthetic peptide derived from the C-terminus of the precursor form of the Human Flk-1

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anti-VEGF Receptor 2 (VEGFR2) (AA 1326-1356), (C-Term) antibody
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应用备注

Western Blotting. Immunohistochemistry on Paraffin Sections: Use a 1/50-1/100 dilution in an ABC method(incubation time: 30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigenunmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended positive control: Angiosarcoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
状态

Liquid

储存条件

4 °C

储存方法

Store the antibody undiluted at 2-8 °C.
抗原

VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

别名

CD309 / VEGFR-2 / Flk-1 (VEGFR2 产品)

别名

CD309 antibody, FLK1 antibody, VEGFR antibody, VEGFR2 antibody, 6130401C07 antibody, Flk-1 antibody, Flk1 antibody, Krd-1 antibody, Ly73 antibody, VEGFR-2 antibody, sVEGFR-2 antibody, Vegfr-2 antibody, FLK-1 antibody, flk-1 antibody, vegfr-2 antibody, KDR antibody, FLK/KDR antibody, flk1 antibody, flk1b antibody, kdrb antibody, si:busm1-205d10.1 antibody, si:ch211-254j6.1 antibody, si:ch211-278f21.4 antibody, wu:fc31a09 antibody, fk52c05 antibody, flk antibody, kdr antibody, kdra antibody, vegfr2 antibody, vegfr4 antibody, vegr2 antibody, wu:fk52c05 antibody, kinase insert domain receptor antibody, kinase insert domain protein receptor antibody, vascular endothelial growth factor receptor kdr-like antibody, kinase insert domain receptor (a type III receptor tyrosine kinase) antibody, kinase insert domain receptor like antibody, KDR antibody, Kdr antibody, LOC100136647 antibody, kdr antibody, kdrl antibody

背景

CD309 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2

基因ID

3791

NCBI登录号

NP_002244

UniProt

P35968

途径

RTK signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling