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Neurofilament, Heavy Polypeptide (NEFH) (C-Term) 抗体

ABIN1108414 产品详细信息, 供应商: Log in to see
抗原
  • NF-H
  • NF200
  • Nfh
  • mKIAA0845
  • NFH
  • NEFH
  • neurofilament heavy polypeptide
  • neurofilament, heavy polypeptide
  • MCYG_06231
  • Nefh
  • NEFH
抗原表位
C-Term
32
18
18
15
9
3
2
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
407
340
319
240
201
99
80
79
56
54
54
52
31
27
26
25
17
3
2
2
2
1
宿主
小鼠
375
54
18
克隆类型 (克隆位点)
单克隆 ()
标记
非结合性
14
13
12
12
12
12
12
12
12
12
12
12
11
11
10
10
9
6
2
2
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
257
227
150
149
122
121
68
56
13
12
8
2
2
2
1
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Available images

免疫原 C-terminal segment of enzymatically dephosphorylated pig Neurofilament 200.
克隆位点 NF-200
亚型 IgG1
特异性 This antibody reacts to Neurofilament H (200 kDa).
纯化方法 Affinity chromatography
别名 Neurofilament H (200 kD) (NEFH Antibody 摘要)
背景 Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 Kd (NFL), 125 kD (NFM), and 200 kD (NFH) on SDS-gel electrophoresis. Genomic clones for the largest human neurofilament protein (NF-H) were isolated, the intron/exon boundaries mapped and the entire protein-coding regions (exons) sequenced. mutations in neurofilaments have been linked to some forms of Charcot-Marie-Tooth disease (CMT)Synonyms: (Neuronal Marker), 200 kDa neurofilament protein, KIAA0845, NEFH, NF-H, NFH, Neurofilament triplet H protein, heavy polypeptide
基因ID 4744
NCBI登录号 NP_066554
UniProt P12036
研究领域 Cytoskeleton, Cell/Tissue Markers
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
溶解方式 Restore with 1.2 % sodium acetate or neutral PBS
浓度 0,1 mg/mL
缓冲液 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 -20 °C
储存方法 Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
厂商提供的图像
Immunohistochemistry (IHC) image for anti-Neurofilament, Heavy Polypeptide (NEFH) (C-Term) 抗体 (ABIN1108414) anti-Neurofilament, Heavy Polypeptide (NEFH) (C-Term) antibody
背景 Brownlees, Ackerley, Grierson, Jacobsen, Shea, Anderton, Leigh, Shaw, Miller: "Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport." in: Human molecular genetics, Vol. 11, Issue 23, pp. 2837-44, 2002 (PubMed).

Lees, Shneidman, Skuntz, Carden, Lazzarini: "The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it." in: The EMBO journal, Vol. 7, Issue 7, pp. 1947-55, 1988 (PubMed).