anti-TYRO Protein tyrosine Kinase Binding Protein (TYROBP) 抗体

TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. 再加上,我们可以发TYROBP 试剂盒 (14)TYROBP 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
TYROBP 361537 Q6X9T7
TYROBP 7305 O43914
TYROBP 22177 O54885
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antibodies-online.cn销售最多的anti-TYROBP 抗体

Showing 10 out of 110 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, FACS, IHC (p), WB TYROBP Antibody (C-term) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. TYROBP Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TYROBP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 IP, WB 0.1 mg Log in to see 6至8个工作日
$390.50
详细
非结合性 IHC, IHC (p), WB Western Blot: DAP12 Antibody [NBP1-85313] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY403671) Immunohistochemistry-Paraffin: DAP12 Antibody [NBP1-85313] - Staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells. 0.1 mL Log in to see 10至13个工作日
$439.69
详细
非结合性 FACS, IHC (p), WB Western blot analysis of TYROBP Antibody (C-term) (ABIN653819) in HepG2 cell line lysates (35 µg/lane). TYROBP (arrow) was detected using the purified polyclonal antibody. TYROBP Antibody (C-term) (ABIN653819) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 WB 100 μg Log in to see 2至3个工作日
$265.00
详细
Bat 山羊 非结合性 IHC (p), ELISA Human Spleen (formalin-fixed, paraffin-embedded) stained with TYROBP antibody ABIN462404 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Uterus (formalin-fixed, paraffin-embedded) stained with TYROBP antibody ABIN462404 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7至9个工作日
$451.00
详细
小鼠 非结合性 CyTOF, FACS, WB Detection of DAP12 in Human CD56+ Natural Killer Cells by Flow Cytometry. Human peripheral blood CD56+ natural killer cells were stained with Human DAP12 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. Detection of Human DAP12 by Western Blot. Western blot shows lysates of NS0 mouse myeloma cell line, mock transfected, and primary human CD56+ NK cells. PVDF membrane was probed with 5 ug/mL of Human DAP12 Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8至9个工作日
$266.70
详细
非结合性 IHC, IHC (p), WB Western Blot: DAP12 Antibody [NBP2-16099] - Western Blot analysis of TYROBP expression in transfected 293T cell line by TYROBP polyclonal antibody. A: Non-transfected lysate. B: TYROBP transfected lysate. 15% SDS PAGE gel, diluted at 1:500. Immunohistochemistry-Paraffin: DAP12 Antibody [NBP2-16099] - Immunohistochemical analysis of paraffin-embedded H1299 xenograft, using antibody at 1:500 dilution. 0.1 mL Log in to see 8至11个工作日
$447.56
详细
山羊 非结合性 EIA, IHC (p) Human Spleen (formalin-fixed, paraffin-embedded) stained with TYROBPfollowed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Uterus (formalin-fixed, paraffin-embedded) stained with TYROBPfollowed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6至8个工作日
$500.50
详细
非结合性 IHC (p), WB Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7至9个工作日
$676.50
详细

通过反应活性、应用领域、克隆类型和共轭标记 TYROBP 抗体

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引用最多的anti-TYROBP 抗体

  1. Human Polyclonal TYROBP Primary Antibody for IHC, IHC (p) - ABIN4304256 : Preusse, Goebel, Pehl, Rinnenthal, Kley, Allenbach, Heppner, Vorgerd, Authier, Gherardi, Stenzel: Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis. in Neuropathology and applied neurobiology 2015 (PubMed)

更多抗TYROBP的相互作用对抗体

Zebrafish TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. The structure of the adaptor protein dap12 has been identified in the zebrafish genome.

  2. DAP12-based activating pathway is conserved between bony fish and mammals

Human TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. Rare TYROBP variants might contribute to early-onset Alzheimer's disease risk by reduction of TREM2 (显示 TREM2 抗体) expression, a well-established risk factor for AD.

  2. TYROBP influences a batch of genes that are related to Alzheimer's disease; ZNF329 (显示 ZNF329 抗体) and RB1 (显示 RB1 抗体) significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.

  3. TYROBP/CSTA (显示 CSTA 抗体) gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis

  4. The different expression of DAP12 compared to TREM2 (显示 TREM2 抗体) represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia.

  5. the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1 (显示 CSF1 抗体)-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation

  6. Impaired signaling by the TREM2 (显示 TREM2 抗体)-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review.

  7. T cells modified to express a KIR (显示 GEM 抗体)-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta (显示 CD247 抗体)-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy.

  8. This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation.

  9. isolated PMNs have an increased proportion of both TREM1 (显示 TREM1 抗体) and DAP12 compared to normal healthy control

  10. results support a role of DAP12 in stabilizing TREM2 (显示 TREM2 抗体)-CTF (显示 NFIA 抗体), thereby protecting against excessive pro-inflammatory responses.

Mouse (Murine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

  1. Recent studies have revealed that activated microglia in the spinal dorsal horn exacerbate neuropathic pain, which has suggested that suppression of microglial activity should be considered as a therapeutic target. However, only a few molecules have been identified as regulators of microglial activity. In this study, we focused on a receptor complex of TREM2 (显示 TREM2 抗体) and DAP12, both of which are expressed by microglia and have bee

  2. TNF (显示 TNF 抗体)/IL-6 (显示 IL6 抗体) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1 (显示 NFATC1 抗体), DNAX-activation protein 12, and cell proliferation.

  3. The findings suggest that DAP12 acts as a brake on the pulmonary immune response to C. neoformans by promoting pulmonary eosinophilia and by inhibiting the activation and antifungal activities of effector cells, including NK cells and macrophages.

  4. significant role of DAP12 in the initial inflammatory response, bone remodeling and regeneration

  5. DAP12-mediated microglial activation following axotomy promotes pro-inflammatory responses, and thereby accelerates nerve injury-induced neuron death

  6. results support a role of DAP12 in stabilizing TREM2 (显示 TREM2 抗体)-CTF (显示 NFIA 抗体), thereby protecting against excessive pro-inflammatory responses.

  7. a previously unrecognized role for DAP12 expression in tissue-resident alveolar macrophages in mediating acute noninfectious tissue injury through regulation of neutrophil trafficking.

  8. DAP12 expression in liver grafts regulates donor mDC (显示 ADAM11 抗体) migration to host lymphoid tissue, alloreactive T cell responses and transplant tolerance

  9. Integrin alphav beta3/Dap12 double-deficient developed profound osteoporosis.

  10. Our study identifies the DAP12/IRAK-M (显示 IRAK3 抗体)/IL-10 (显示 IL10 抗体) to be a novel molecular pathway in APCs (显示 APCS 抗体) exploited by mycobacterial pathogens, allowing infection a foothold in the lung.

Cow (Bovine) TYRO Protein tyrosine Kinase Binding Protein (TYROBP) interaction partners

TYROBP 抗原简介

蛋白简介

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with TYROBP

  • TYRO protein tyrosine kinase binding protein (TYROBP) 抗体
  • TYRO protein tyrosine kinase binding protein (tyrobp) 抗体
  • Tyro protein tyrosine kinase binding protein (Tyrobp) 抗体
  • TYRO protein tyrosine kinase binding protein (Tyrobp) 抗体
  • dap12 抗体
  • KARAP 抗体
  • Ly83 抗体
  • PLOSL 抗体
  • TYROBP 抗体
  • tyrpbp 抗体

Protein level used designations for TYROBP

TYRO protein tyrosine kinase-binding protein , TYRO protein tyrosine kinase binding protein , DAP12 protein , dap12 , DAP12 , DNAX-activation protein 12 , killer cell activating receptor-associated protein , KAR-associated protein , killer activating receptor associated protein , killer-activating receptor-associated protein , killer cell activating receptor associated protein , immunoreceptor DAP12 , tyrosine kinase binding protein

GENE ID SPECIES
476477 Canis lupus familiaris
443208 Ovis aries
100101461 Danio rerio
361537 Rattus norvegicus
7305 Homo sapiens
22177 Mus musculus
282390 Bos taurus
397405 Sus scrofa
574207 Macaca mulatta
455968 Pan troglodytes
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