anti-Myosin Light Chain Kinase (MYLK) 抗体

MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. 再加上,我们可以发Myosin Light Chain Kinase 试剂盒 (27)Myosin Light Chain Kinase 蛋白 (13)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MYLK 4638 Q15746
MYLK 288057  
MYLK 107589  

antibodies-online.cn销售最多的anti-Myosin Light Chain Kinase 抗体

Showing 10 out of 94 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IHC (p), WB Western blot analysis of MYLK3 Antibody (N-term) (ABIN392494) in A375 cell line lysates (35 µg/lane). MYLK3(arrow) was detected using the purified polyclonal antibody. Western blot analysis of anti-MYLK3 Antibody (N-term) (ABIN392494) in mouse heart tissue lysates (35 µg/lane). MYLK3(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 5至8个工作日
¥2,325.14
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非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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非结合性 EIA, IHC (p), WB Western blot analysis in K562 cell line lysates (35ug/lane) using MLCK Antibody . This demonstrates this antibody detected the MLCK protein (arrow). 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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小鸡 非结合性 WB Western blot analysis of MLCK1 expression in HeLa (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 7至8个工作日
¥3,941.44
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非结合性 IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of anti-MLCK-long Pab (ABIN392495) in mouse brain tissue lysate. MLCK-long (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 400 μL Log in to see 5至8个工作日
¥2,325.14
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小鸡 山羊 非结合性 ELISA, WB 100 μg Log in to see 29至35个工作日
¥6,088.05
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山羊 非结合性 ELISA, WB 0.1 mg Log in to see 24至29个工作日
¥4,732.45
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非结合性 ELISA, WB   100 μg Log in to see 24至29个工作日
¥3,026.87
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小鼠 非结合性 ICC, IHC, IP, WB 100 μg Log in to see 7至10个工作日
¥1,742.48
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通过反应活性、应用领域、克隆类型和共轭标记 MYLK 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Myosin Light Chain Kinase 抗体

  1. Human Polyclonal MYLK Primary Antibody for IHC (p), WB - ABIN392494 : Rossi, Ralay Ranaivo, Patel, Chrzaszcz, Venkatesan, Wainwright: Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase. in Journal of neuroscience research 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal MYLK Primary Antibody for IHC (p), WB - ABIN392495 : Rossi, Todd, Daniels, Bazan, Belayev: Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice. in Journal of neurotrauma 2015 (PubMed)
    Show all 2 Pubmed References

更多抗Myosin Light Chain Kinase的相互作用对抗体

Human Myosin Light Chain Kinase (MYLK) interaction partners

  1. loss of MLCK contributes to the migratory properties of epithelial cells resulting from changes in cell-cell and cell-matrix adhesions, and increased epidermal growth factor receptor (显示 EGFR 抗体) signaling.

  2. Sixty-seven experienced runners competed in a marathon race. The MLCK genotype (C37885A) of these marathoners was determined. CA heterozygotes for MLCK C37885A might present higher exercise-induced muscle damage after a marathon competition than CC counterparts.

  3. these Acute respiratory distress syndrome (ARDS)-associated MYLK cytosine-guanine dinucleotides with effect modification by ethnicity and local modified cytosine quantitative trait loci suggest that MYLK epigenetic variation and local genetic background may contribute to health disparities observed in ARDS.

  4. mechanical stress and MYLK single nucleotide polymorphism regulate MYLK alternative splicing.

  5. Rebeccamycin attenuates TNF-alpha (显示 TNF 抗体)-induced disruption of intestinal epithelial barrier integrity by inducing claudin-5 (显示 CLDN5 抗体) expression and suppressing MLCK production via Chk1 (显示 CHEK1 抗体) activation.

  6. Data show that alterations in myosin light chain kinase activity, claudin-15 (显示 CLDN15 抗体) and claudin-2 (显示 CLDN2 抗体) expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).

  7. PXR (显示 NR1I2 抗体) regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK expression and JNK1 (显示 MAPK8 抗体)/2 activation

  8. A 2-bp deletion in myosin light chain kinase (c3272_3273del, p.Ser1091*) that led to a premature stop codon have a high risk of presenting with an acute aortic dissection or rupture.

  9. In contrast to mylk2 (显示 MYLK2 抗体) and mylk3 (显示 MYLK3 抗体), mylk1 has a complex structure, and multiple protein products of the mylk1 gene are expressed in most if not all cell types. This review deals with the mylk1 gene and its protein products- multiple MLCK isoforms and noncatalytic KRP/telokin protein. [Review]

  10. Likely pathogenic variants included a TGFB2 (显示 TGFB2 抗体) variant in one patient and a SMAD3 (显示 SMAD3 抗体) variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5 (显示 MFAP5 抗体), which were identified in a third patient

Cow (Bovine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.

Rabbit Myosin Light Chain Kinase (MYLK) interaction partners

  1. evaluated the spatial arrangement of the catalytic/regulatory domain, three immunoglobulin-related motifs, one fibronectin-related motif, a repetitive, proline-rich segment, and, at the N-terminus, a unique F-actin-binding domain.

Mouse (Murine) Myosin Light Chain Kinase (MYLK) interaction partners

  1. telokin may play a role in attenuating constitutive myosin light chain phosphorylation

  2. MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation

  3. NF-kappaB (显示 NFKB1 抗体) novel partner within endothelial cells

  4. MLCK regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.

  5. nmMlck modulates IL-1beta (显示 IL1B 抗体)-mediated downregulation of Cldn5 (显示 CLDN5 抗体) in brain microvascular endothelial cells.

  6. a prominent effect of the multifunctional microRNA-155 in endothelial cells is modulation of phenotype through alterations in RhoA, myosin light chain kinase expression, and actin cytoskeleton organization

  7. CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility

  8. In immune-mediated inflammatory bowel disease, tight junction dysregulation and barrier loss is induced by MLCK, but at advanced stages, barrier loss is MLCK-independent.

  9. Claudin-2 (显示 CLDN2 抗体) assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.

  10. involved in IL-1beta (显示 IL1B 抗体)-induced increase in intestinal permeability

Myosin Light Chain Kinase (MYLK) 抗原简介

蛋白简介

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

Gene names and symbols associated with MYLK

  • myosin light chain kinase (MYLK) 抗体
  • myosin light chain kinase (Mylk) 抗体
  • myosin, light polypeptide kinase (Mylk) 抗体
  • 9530072E15Rik 抗体
  • A930019C19Rik 抗体
  • AAT7 抗体
  • AW489456 抗体
  • KRP 抗体
  • Mlck 抗体
  • MLCK1 抗体
  • MLCK108 抗体
  • MLCK210 抗体
  • MSTP083 抗体
  • MYLK1 抗体
  • SMMLCK 抗体

Protein level used designations for MYLK

kinase related protein, telokin , myosin, light chain kinase , myosin light chain kinase , myosin light chain kinase, smooth muscle-like , kinase-related protein , myosin light chain kinase, smooth muscle , myosin, light polypeptide kinase , smooth muscle myosin light chain kinase , telokin , MLCK , smooth muscle myosin light chain kinase (61-kDa active fragment)

GENE ID SPECIES
460640 Pan troglodytes
488012 Canis lupus familiaris
715422 Macaca mulatta
100481263 Ailuropoda melanoleuca
4638 Homo sapiens
288057 Rattus norvegicus
338037 Bos taurus
396848 Sus scrofa
100009143 Oryctolagus cuniculus
443334 Ovis aries
396445 Gallus gallus
100714177 Cavia porcellus
107589 Mus musculus
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