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MYLK 抗体 (C-Term)

Name: MYLK 抗体 (C-Term)
SKU: ABIN6263474
Availability: OutOfStock

MYLK 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of MYLK expression in HepG2 cells. (MYLK 抗体 (C-Term))

Western blot analysis of MYLK expression in mouse brain (MYLK 抗体 (C-Term))

Western blot analysis of extracts from mouse muscle, using MYLK Antibody. (MYLK 抗体 (C-Term))

3 images

产品编号 ABIN6263474

发货至: 中国

Datasheet as PDF

抗原 See all MYLK 抗体

MYLK (Myosin Light Chain Kinase (MYLK))
抗原表位
15

8

8

7

5

4

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
79

41

34

2

2

1

1
人, 小鼠, 大鼠
宿主
87

4

3

1
兔
Compatible Secondaries
克隆类型
82

13
多克隆
标记
42

8

5

5

5

5

5

5

5

3

1

1

1

1

1

1

1
This MYLK antibody is un-conjugated
应用范围
39

35

25

13

13

12

5

5

4

4

3

2

1

1
Western Blotting (WB), ELISA

特异性

MLCK Antibody detects endogenous levels of total MLCK.

预测反应

Bovine,Sheep,Rabbit,Dog,Chicken

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human MLCK, corresponding to a region within C-terminal amino acids.

亚型

IgG

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anti-Myosin Light Chain Kinase (MYLK) (AA 1684-1884) antibody
MYLK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Myosin Light Chain Kinase (MYLK) (AA 1441-1709) antibody
MYLK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myosin Light Chain Kinase (MYLK) (AA 1765-1914) antibody
MYLK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myosin Light Chain Kinase (MYLK) (AA 923-953), (N-Term) antibody
MYLK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB03067 unconjugated

anti-Myosin Light Chain Kinase (MYLK) (AA 908-938) antibody
MYLK 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Myosin Light Chain Kinase (MYLK) (AA 1661-1877) antibody
MYLK 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Myosin Light Chain Kinase (MYLK) antibody
MYLK 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated

anti-Myosin Light Chain Kinase (MYLK) (AA 1-992) antibody
MYLK 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Myosin Light Chain Kinase (MYLK) (AA 908-938) antibody
MYLK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

MYLK (Myosin Light Chain Kinase (MYLK))

别名

MYLK (MYLK 产品)

别名

AAT7 antibody, KRP antibody, MLCK antibody, MLCK1 antibody, MLCK108 antibody, MLCK210 antibody, MSTP083 antibody, MYLK1 antibody, smMLCK antibody, 9530072E15Rik antibody, A930019C19Rik antibody, AW489456 antibody, Mlck antibody, SMMLCK antibody, mlck antibody, fj60a06 antibody, mlck1a antibody, mylk antibody, wu:fj60a06 antibody, zmlck1 antibody, myosin light chain kinase antibody, myosin, light polypeptide kinase antibody, myosin, light chain kinase a antibody, MYLK antibody, Mylk antibody, mylka antibody

背景

Description: Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury, triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca2+ entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells. Responsible for high proliferative ability of breast cancer cells through anti-apoptosis.
Gene: MYLK

分子量

211 kDa.

基因ID

4638

UniProt

Q15746