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The protein encoded by MAPK8IP3 shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. 再加上，我们可以发和数多这个蛋白质的别的产品。
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Mouse (Murine) Polyclonal MAPK8IP3 Primary Antibody for IHC (p), IHC - ABIN249901
Kelkar, Gupta, Dickens, Davis: Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. in Molecular and cellular biology 2000
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
The crystal structure of an N-terminally truncated form of LZII of JIP3 alone shows an unexpected antiparallel arrangement.
Results demonstrated the increased expression of JIP3 in the temporal neocortex of TLE patients and in the experimental model of epileptic seizures
JSAP1 and JLP (显示 SPAG9 抗体) play critical roles in kinesin-1-dependent axonal transport
The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin (显示 PPFIA1 抗体)-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions
This study demonistrated that JIP3 mediates TrkB (显示 NTRK2 抗体) axonal anterograde transport and enhances BDNF (显示 BDNF 抗体) signaling by directly bridging TrkB (显示 NTRK2 抗体) with kinesin-1.
Expression of constitutively active PI3K (显示 PIK3CA 抗体) stimulated translocation of Tiam1 (显示 TIAM1 抗体) to the membrane, increased Rac1 activity, and increased wound healing of airway epithelial cells. Increased Rac1 activity resulted in increased phosphorylation of JNK1 (显示 MAPK8 抗体).
demonstration that JSAP1 bound ASK1 (显示 MAP3K5 抗体) and enhanced ASK1 (显示 MAP3K5 抗体)- and H2O2-induced JNK (显示 MAPK8 抗体) activity
Pressure application of 160 mmHg for 3 h produced cell proliferation and activated ERK (显示 EPHB2 抗体) and c-JUN N-terminal kinase
JIP1 (显示 MAPK8IP1 抗体) and JIP3, have a cross-talk that leads to the regulation of the ASK1 (显示 MAP3K5 抗体)-SEK1 (显示 MAP2K4 抗体)-JNK (显示 MAPK8 抗体) signal during glucose deprivation; cross-talk between JIP3 and JIP1 (显示 MAPK8IP1 抗体) is mediated through SEK1 (显示 MAP2K4 抗体)-JNK2 (显示 MAPK9 抗体) and Akt1 (显示 AKT1 抗体).
JSAP1.FAK (显示 PTK2 抗体) complex functions cooperatively as a scaffold for the JNK (显示 MAPK8 抗体) signaling pathway and regulator of cell migration on FN
These results establish the critical role of JIP3-dependent axonal lysosome transport in regulating amyloidogenic amyloid precursor protein (显示 APP 抗体) processing and support a model wherein Abeta (显示 APP 抗体) production is amplified by plaque-induced axonal lysosome transport defects.
Data show that c-Jun NH2-terminal kinase (JNK (显示 MAPK8 抗体))-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB (显示 NTRK2 抗体) receptor axonal anterograde transport.
JSAP1/JIP3 and JLP (显示 SPAG9 抗体) regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration
These findings reveal that JIP3 regulation of kinesin-1 motility is critical for axon elongation and regeneration.
JSAP1 and JLP (显示 SPAG9 抗体), which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 (显示 ARF6 抗体) localization to the midbody by forming a tripartite complex of JSAP1/JLP (显示 SPAG9 抗体), active ARF6 (显示 ARF6 抗体), and kinesin-1.
JIP3 regulates neuronal axon elongation in a kinesin- and JNK (显示 MAPK8 抗体)-dependent manner
Results suggest that JSAP1 is required for the pathfinding of the developing telencephalic commissures in the early brains.
syd activates kinesin heavy chain for transport & enhances its motility, increasing its velocity & run length. syd mutants binding KHC but not kinesin light chain are transported to axons & dendrites normally.
The results provide evidence that ARF6 (显示 ARF6 抗体)/JIP3 signaling regulates neurite morphogenesis.
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
mitogen-activated protein kinase 8 interacting protein 3
, C-Jun-amino-terminal kinase-interacting protein 3
, JNK-interacting protein 3
, c-Jun-amino-terminal kinase-interacting protein 3-like
, C-jun-amino-terminal kinase interacting protein 3
, JNK MAP kinase scaffold protein 3
, JNK/SAPK-associated protein-1
, JNK/stress-activated protein kinase-associated protein 1
, homolog of Drosophila Sunday driver 2
, mitogen-activated protein kinase 8-interacting protein 3
, JNK/SAPK-associated protein 1
, JNK/SAPK-associated protein 1c
, JUN/SAPK-associated protein 1
, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1
, mitogen activated protein kinase 8 interacting protein 3
, sunday driver 2