C-Type Lectin Domain Family 1, Member B 蛋白 (CLEC1B)

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. 再加上,我们可以发C-Type Lectin Domain Family 1, Member B 抗体 (126)C-Type Lectin Domain Family 1, Member B 试剂盒 (1)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CLEC1B 51266 Q9P126
CLEC1B 56760 Q9JL99
大鼠 CLEC1B CLEC1B 500336  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
$4,244.78
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HEK-293 小鼠 Fc Tag 100 μg Log in to see 10至12个工作日
$587.01
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人细胞 His tag 100 μg Log in to see 20至21个工作日
$382.80
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人细胞 小鼠 Fc Tag 100 μg Log in to see 20至21个工作日
$382.80
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$405.71
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大肠杆菌(E. Coli) His tag   100 μg Log in to see 2至3个工作日
$418.88
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CLEC1B 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Mouse (Murine) , ,
, ,

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Human C-Type Lectin Domain Family 1, Member B (CLEC1B) interaction partners

  1. Data (including data from studies using cells from knockout mice) suggest that CLEC2/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ (显示 GNAQ 蛋白) agonists. (CLEC2 = C-type lectin (显示 MBL2 蛋白) CLEC2; CLEC2R = CLEC2 receptor; GNAQ (显示 GNAQ 蛋白) = guanine nucleotide-binding protein (显示 COASY 蛋白) G[q] subunit alpha)

  2. NZ-1 inhibits the hPDPN-CLEC-2 interaction and is also useful for anti-PA tag MAb.The minimum epitope of LpMab-13 was identified as Ala42-Asp49 of hPDPN using Western blot and flow cytometry. The combination of different epitope-possessing MAbs could be advantageous for the hPDPN-targeting diagnosis and therapy

  3. CLEC2 prevents expression of PI3K (显示 PIK3CA 蛋白) subunits, in a SYK (显示 SYK 蛋白)-dependent manner, to suppress the invasive activities of gastric cancer cells.

  4. CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion.

  5. Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation (显示 CD36 蛋白) of C (显示 GP6 蛋白)D36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2).

  6. PI3K (显示 PIK3CA 蛋白) and Tec (显示 NR4A3 蛋白) family kinases play a crucial role in the regulation of platelet activation and Syk (显示 SYK 蛋白) phosphorylation downstream of the CLEC-2 receptor

  7. fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway

  8. Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade

  9. A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation.

  10. The glycosylation sites (N120 and N134) are necessary for the surface expression of CLEC-2.

Mouse (Murine) C-Type Lectin Domain Family 1, Member B (CLEC1B) interaction partners

  1. a novel mechanism of Deep vein thrombosis, whereby CLEC-2 and upregulation of podoplanin (显示 PDPN 蛋白) expression in the venous wall trigger thrombus formation

  2. A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN (显示 PDPN 蛋白) on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM.

  3. A role for CLEC2 as a regulator of macrophage polarity and Kupffer cell polarity, lipid and glucose homeostasis

  4. Data indicate that C-type lectin-like receptor-2 (CLEC-2) is highly expressed on bone marrow megakaryocytes (Mks (显示 MKKS 蛋白)).

  5. Data (including data from studies in transgenic mice) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of Cd36 (显示 CD36 蛋白)/GPVI (显示 GP6 蛋白) (glycoprotein VI) and/or Clec-2 (C-type lectin-like receptor-2).

  6. Podoplanin (显示 PDPN 蛋白) and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels.

  7. PI3K and Tec (显示 NR4A3 蛋白) family kinases play a crucial role in the regulation of platelet activation and Syk (显示 SYK 蛋白) phosphorylation downstream of the CLEC-2 receptor

  8. CLEC-2 signaling promotes adhesion to Podoplanin (显示 PDPN 蛋白) and regulation of Podoplanin (显示 PDPN 蛋白) signaling, thereby contributing to lymphatic vasculature development.

  9. Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN (显示 PDPN 蛋白) receptor CLEC-2, PDPN (显示 PDPN 蛋白) endowed FRCs with contractile function and exerted tension within the reticulum.

  10. Functional studies of platelets from Ceacam2 (显示 CEACAM2 蛋白)(-/-)-deficient mice (Cc2 (显示 TSG101 蛋白)(-/-)) revealed that CEACAM2 (显示 CEACAM2 蛋白) serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI (显示 GP6 蛋白))-FcRgamma (显示 FCER1G 蛋白)-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling

蛋白简介C-Type Lectin Domain Family 1, Member B (CLEC1B)

蛋白简介

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000

Gene names and symbols associated with CLEC1B

  • C-type lectin domain family 1 member B (CLEC1B)
  • C-type lectin domain family 1, member b (Clec1b)
  • C-type lectin domain family 1, member B (Clec1b)
  • C-type lectin domain family 1, member B (CLEC1B)
  • C-type lectin domain family 1 member B (Clec1b)
  • 1810061I13Rik 蛋白
  • Clec-2 蛋白
  • CLEC1B 蛋白
  • Clec2 蛋白
  • CLEC2B 蛋白
  • CLEC9A 蛋白
  • PRO1384 蛋白
  • QDED721 蛋白
  • RGD1563517 蛋白

Protein level used designations for CLEC1B

C-type lectin domain family 1 member B , C-type lectin-like receptor 2 , C-type lectin-like receptor-2 , CLEC-2 , C-type lectin domain family 1, member B , c-type lectin domain family 1 member B-like , C-type lectin domain containing 9A , C-type lectin domain family 9 member A

GENE ID SPECIES
51266 Homo sapiens
56760 Mus musculus
465283 Pan troglodytes
500336 Rattus norvegicus
784092 Bos taurus
100346882 Oryctolagus cuniculus
717404 Macaca mulatta
100726289 Cavia porcellus
100053758 Equus caballus
611394 Canis lupus familiaris
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