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BUB1B encodes a kinase involved in spindle checkpoint function. 再加上，我们可以发BUB1B 蛋白 (8) 和 BUB1B 试剂盒 (1)和数多这个蛋白质的别的产品。
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Human Monoclonal BUB1B Primary Antibody for CyTOF, FACS - ABIN151818
Chan, Jablonski, Sudakin, Hittle, Yen: Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. in The Journal of cell biology 1999
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Human Monoclonal BUB1B Primary Antibody for IHC (p), PLA - ABIN560109
Chambers: The molecular basis of pluripotency in mouse embryonic stem cells. in Cloning and stem cells 2005
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Human Polyclonal BUB1B Primary Antibody for IP, WB - ABIN152011
Tang, Erikson, Liu: Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). in Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Polyclonal BUB1B Primary Antibody for WB - ABIN2801914
Donadelli, Benatti, Remuzzi, Morigi, Gullans, Benigni, Remuzzi, Noris: Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress. in Biochemical and biophysical research communications 1998
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Human Monoclonal BUB1B Primary Antibody for IF, WB - ABIN968854
Mizunuma, Hirata, Miyahara, Tsuchiya, Miyakawa: Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. in Nature 1998
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Human Monoclonal BUB1B Primary Antibody for IF, WB - ABIN968853
Wu, Lan, Li, Wu, Weinstein, Sakamoto, Dai: p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase. in Oncogene 2000
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Human Polyclonal BUB1B Primary Antibody for ICC, IF - ABIN251710
On, Chen, Ma, Chow, Poon: Determinants of mitotic catastrophe on abrogation of the G2 DNA damage checkpoint by UCN-01. in Molecular cancer therapeutics 2011
Human Monoclonal BUB1B Primary Antibody for ICC, IF - ABIN2668286
Liu, Rattner, Jablonski, Yen: Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. in The Journal of cell biology 2006
Human Polyclonal BUB1B Primary Antibody for IF (p), IHC (p) - ABIN713831
Qu, Zou, Zhang, Sheng, Wang, Wang, Wang, Ji: Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells. in Molecular medicine reports 2016
Together, our findings demonstrate that Bub1 (显示 BUB1 抗体) acts at multiple points to assure the correct kinetochore formation.
The Bub3 (显示 BUB3 抗体)-BubR1 complex on broken DNA inhibits the APC (显示 APC 抗体)/C locally via the sequestration of Cdc20 (显示 CDC20 抗体).
a model in which Polo (显示 PLK1 抗体) controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (显示 CDC20 抗体) kinetochore recruitment and sustained SAC (显示 ADCY10 抗体) function.
Data show that the Mad2 (显示 MAD2L1 抗体) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (显示 CDC20 抗体) to kinetochores in Drosophila requires BubR1 but not Mad2 (显示 MAD2L1 抗体).
Reduced BubR1 or Polo (显示 PLK1 抗体) function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.
BubR1's role in mitosis is discussed.
BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis
BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (显示 CENPE 抗体).
Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (显示 CDC20 抗体)-APC (显示 APC 抗体) function, preventing the metaphase-to-anaphase transition.
Results from phylogenomic study identified of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint
BubR1 N-terminal domain was necessary, but not sufficient to protect against aneuploidy and cancer. In contrast, BubR1 lacking the internal Cdc20 (显示 CDC20 抗体)-binding domain provided protection against both, which coincided with improved microtubule-kinetochore attachment error correction and spindle assembly checkpoint activity.
Low BUB1B expression is associated with Chromophobe Renal Cell Carcinomas.
Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (显示 MYO5A 抗体) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors
structure of the PP2A (显示 PPP2R4 抗体) B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A (显示 PPP2R4 抗体) to specific targets.
Overexpression of BUB1B is associated with Invasive Breast Cancer.
we showed that BubR1 and Mad2 (显示 MAD2L1 抗体) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.
The integrity of the mitotic checkpoint (显示 BUB3 抗体) complex depends on the specific recognition between BubR1 and Bub3 (显示 BUB3 抗体), for which the BubR1 Gle2 (显示 RAE1 抗体) binding sequence motif is essential.
We show that kinetochore recruitment of BUBR1 and BUB3 (显示 BUB3 抗体) by BUB1 (显示 BUB1 抗体) is dispensable for SAC (显示 ADCY10 抗体) activation
Data suggest that both BubR1 and SNCG may be promising predictive marker rather than prognostic marker in patients with breast cancer.
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Consistent with defective myelination, BubR1(H/H) mice exhibited various motor deficits, including impaired motor strength, coordination, and balance, irregular gait patterns and reduced locomotor activity.
EZH2 (显示 EZH2 抗体) directly interacted with and stabilized BubR1, an effect driving EZH2 (显示 EZH2 抗体) into the concert of meiosis regulation.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (显示 BUB3 抗体), and Ercc1 (显示 ERCC1 抗体)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (显示 ERCC1 抗体)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (显示 SGOL1 抗体) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.
These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.
BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.
Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.
the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (显示 SIRT2 抗体) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (显示 CREBBP 抗体).
BubR1 insufficiency elicits an aging response that is counteracted by p53 (显示 TP53 抗体) and involves single or multiple p53 (显示 TP53 抗体) targets, depending on the tissue type.
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog beta
, budding uninhibited by benzimidazoles 1 beta
, budding uninhibited by benzimidazoles 1 homolog beta
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta
, budding uninhibited by benzimidazoles 1 homolog beta (yeast)
, mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like
, bub related one
, MAD3/BUB1-related protein kinase
, mitotic checkpoint kinase MAD3L
, budding uninhibited by benzimidazoles 1 homolog, beta