(X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
Silva, Stambaugh, Yokomori, Shah, Berns: "DNA damage to a single chromosome end delays anaphase onset." in: The Journal of biological chemistry, Vol. 289, Issue 33, pp. 22771-84, (2014) (PubMed).
Ali, Jukes, Pearl, Oliver: "Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK." in: Nucleic acids research, Vol. 37, Issue 5, pp. 1701-12, (2009) (PubMed).
Iles, Rulten, El-Khamisy, Caldecott: "APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks." in: Molecular and cellular biology, Vol. 27, Issue 10, pp. 3793-803, (2007) (PubMed).