XPC 抗体
(Xeroderma Pigmentosum, Complementation Group C (XPC))
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
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Latest Publications for our XPC 抗体
: "Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[a]Pyrene Metabolite Profile and Its Distribution in 3D Skin." in: mBio, Vol. 12, Issue 5, pp. e0122321, (2022) (PubMed).: "Polynuclear ruthenium organometallic compounds induce DNA damage in human cells identified by the nucleotide excision repair factor XPC." in: Bioscience reports, Vol. 39, Issue 7, (2019) (PubMed).
: "Identification of four novel XPC mutations in two xeroderma pigmentosum complementation group C patients and functional study of XPC Q320X mutant." in: Gene, Vol. 628, pp. 162-169, (2017) (PubMed).
: "Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics." in: Journal of proteome research, Vol. 15, Issue 12, pp. 4505-4517, (2016) (PubMed).
: "E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis." in: Cancer research, Vol. 74, Issue 12, pp. 3369-77, (2014) (PubMed).
: "Nucleotide excision repair activity on DNA damage induced by photoactivated methylene blue." in: Free radical biology & medicine, Vol. 61, pp. 343-56, (2014) (PubMed).
: "ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency." in: Cancer research, Vol. 74, Issue 10, pp. 2835-45, (2014) (PubMed).
: "Sodium arsenite ± hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 127, Issue 1, pp. 139-49, (2012) (PubMed).
: "Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity." in: Experimental cell research, Vol. 318, Issue 16, pp. 1973-86, (2012) (PubMed).
: "Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal ..." in: Journal of ovarian research, Vol. 4, pp. 9, (2011) (PubMed).
Aliases for XPC 抗体
XPC complex subunit, DNA damage recognition and repair factor (XPC) 抗体xeroderma pigmentosum, complementation group C (Xpc) 抗体
XPC complex subunit, DNA damage recognition and repair factor (Xpc) 抗体
RAD4 抗体
XP3 抗体
XPCC 抗体
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