Use your antibodies-online credentials, if available.
抗Human TCF7 抗体:
抗Rat (Rattus) TCF7 抗体:
抗Mouse (Murine) TCF7 抗体:
High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (显示 MLLT11 抗体)/TCF7/CD44 (显示 CD44 抗体) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (显示 GIP 抗体)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (显示 CTNNB1 抗体) signaling due to the dissociation of beta-catenin (显示 CTNNB1 抗体)/TCF-1 (显示 HNF1A 抗体) complex and the process was orchestrated by STAT-3 (显示 STAT3 抗体).
we show that TCF7 is a direct target of miR (显示 MLXIP 抗体)-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt (显示 WNT2 抗体) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 (显示 RUNX2 抗体) signaling pathways with their partners TCF7 and FGFR1 (显示 FGFR1 抗体)/2 may not be involved in CCD (显示 RUNX2 抗体) pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF (显示 HNF4A 抗体) transcription factor pathway response blocker to treat WNT (显示 WNT2 抗体)-TCF (显示 HNF4A 抗体)-dependent diseases including multiple cancers.
miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT (显示 TERT 抗体) and the TCF7 transcription factor, which mediates the canonical Wnt (显示 WNT2 抗体) pathway.
This is attributed in part to ineffective repression of Tcf1 (显示 HNF1A 抗体) expression in knockout T cells, as DNMT3a (显示 DNMT3A 抗体) localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8 (显示 CD8A 抗体)(+) T cells. These data identify DNMT3a (显示 DNMT3A 抗体) as a crucial regulator of CD8 (显示 CD8A 抗体)(+) early effector cell differentiation and effector versus memory fate decisions.
The balance between CD4 (显示 CD4 抗体)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 (显示 BCL6 抗体) and Tcf7 (encoding TCF-1 (显示 HNF1A 抗体)) and by the expression of the inhibitory receptors PD-1 (显示 PDCD1 抗体) and LAG3 (显示 LAG3 抗体).
data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8 (显示 CD8A 抗体)(+) and CD4 (显示 CD4 抗体)(+) T cell responses to viral infection
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (显示 GIP 抗体) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (显示 MLXIP 抗体)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (显示 HNF1A 抗体) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (显示 MLXIP 抗体)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
TCF-1 (显示 HNF1A 抗体) was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 (显示 HNF1A 抗体) promoted Bcl-6 (显示 BCL6 抗体) expression but repressed Blimp1 (显示 PRDM1 抗体) expression.
Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 (显示 CCR7 抗体) as Foxo1 (显示 FOXO1 抗体)-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking.
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, transcription factor 7, T-cell specific
, T cell factor-1
, T-cell factor 1