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抗Human TCF7 抗体:
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Human Polyclonal TCF7 Primary Antibody for ELISA, WB - ABIN544734
Noble, White, Lazzeroni, Valdes, Mirel, Reynolds, Grupe, Aud, Peltz, Erlich: A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. in Diabetes 2003
Show all 3 Pubmed References
sSudy described a TCF7-dependent feedback control of the osteocalcin-GPRC6A axis in brown adipocyte physiologies.
Downregulation of lncTCF7 significantly inhibits migration and invasion of CRC cells by inhibiting TCF7 expression, suggesting that lncTCF7 may be a potential target for CRC therapy.
Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/beta-catenin pathway.
Results demonstrated that TCF7 expression is upregulated by LOC728196 which operates as the sponge for miR-513c contributing to glioma cell growth and invasion by modulating.
LncRNATCF7 overexpression promoted the proliferation and migration of brain neoplasm glioma cells.
The results showed SNPs near TCF7 were associated with decreased expression of TCF7 mRNA in PBMCs from patients with SLE and suggested that the mRNA expression of the gene may be correlated with the pathogenesis of SLE.
We demonstrated that the AR-miR-1 axis negatively regulates the novel oncogenic factor, TCF7. Dysregulation of TCF7 promoted a survival advantage and resistance to androgen deprivation, suggesting its therapeutic potential for castration-resistant prostate cancer.
It promotes invasiveness and self-renewal of human non-small cell lung cancer cells. The potential role of lncTCF7 up regulation in NSCLC metastasis and suggest a promising potential to suppress lncTCF7 for NSCLC patients.
High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q/TCF7/CD44 regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.
we show that TCF7 is a direct target of miR-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 signaling pathways with their partners TCF7 and FGFR1/2 may not be involved in CCD pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF transcription factor pathway response blocker to treat WNT-TCF-dependent diseases including multiple cancers.
miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT and the TCF7 transcription factor, which mediates the canonical Wnt pathway.
we establish that ATF2 family members physically and functionally interact with TCF1/LEF1 factors to promote target gene expression and hematopoietic tumor cell growth
Studied the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC).
TCF-1 both enhances HEB protein stability and functionally cooperates with HEB in defining the epigenetic and transcriptional status of CD4(+)CD8(+) thymocytes
The requirement of TCF-1 in vivo at stages earlier than double-positive cells to restrain peripheral Th17 immunity by directly binding and inhibiting IL-17 promoter.
Study described a TCF7-dependent feedback control of the osteocalcin-GPRC6A axis in brown adipocyte physiologies.
Tcf4 and Tcf1 mutants showed severe caudal truncations, as well as duplications of the neural tube
Fascin is a novel target of beta-catenin-TCF signaling and is expressed at the invasive front of human colon cancer
UCH L1 up-regulates its expression by activation of the oncogenic beta-catenin/TCF signaling
beta-catenin/Tcf signaling acts as a switch that determines the outcome of thymic selection downstream the alphabetaTCR cascade
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells
the interaction between Hhex and SOX13 may contribute to control Wnt/TCF1 signaling in the early embryo.
beta-catenin, Lef1 & Tcf1 are needed for Bmp4 expression maintaining Shh expression in the dental ectoderm. The number of incisors from one placode can be varied through local changes of a mesenchymal signaling circuit involving these proteins.
Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis
data suggest a model where Notch signals induce TCF-1, and TCF-1 in turn imprints the T-cell fate by upregulating expression of T-cell essential genes
Loss of TCF-1 expression impaired the capacity of these innate lymphoid cell subsets to produce IL-5, IL-13, and IL-22 and resulted in crippled responses to intestinal infection with Citrobacter rodentium.
IP3R-mediated Ca2+ signaling reinforces Tcf-1 activity to both ensure normal development and to prevent thymocyte neoplasia.
TCF-1 physically interacted with Runx3 to cooperatively silence Cd4.
This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions.
critical for suppression of CD8-positive T-cell function
this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1, GATA-3 and Runx1) activate Bcl11b for T cell commitment
Lef1 and Tcf1 showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members.
this study found that virus-specific CD8(+) T cells that sustained the T cell response during chronic viral infection are defined by, and depended on, the expression of Tcf1
C-terminal splice variants of correspond to human B, C, and D isoforms
The results indicate that in post-gastrula stage Xenopus embryos, the E-tail of Tcf1 is required for expression of Lef1 and for blood vessel formation.
results indicate that tcf1 acts as an essential activator of foxd3, which is critical for dorsal mesoderm formation in early embryos
Data indicte that Tcf-1 and Lef-1 exhibit a function in the axis induction assay, which is lacking in Tcf-3 and Tcf--4.
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, T cell factor-1
, T-cell factor 1
, transcription factor 7, T-cell specific
, transcription factor 7 (T-cell specific, HMG-box)
, T-cell factor 7
, T cell-specific transcription factor 1
, transcription factor 7 (T-cell specific, HMG-box) S homeolog
, transcription factor 7 S homeolog