Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-630 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (By similarity).
Das, Taylor, Gireud, Singh, Lee, Fuller, Ji, Fangusaro, Rajaram, Goldman, Eberhart, Gopalakrishnan: "The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation." in: Oncogene, Vol. 32, Issue 13, pp. 1691-701, (2013) (PubMed).
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
Aliases for USP37 抗体
ubiquitin specific peptidase 37 (USP37) 抗体 ubiquitin specific peptidase 37 (usp37) 抗体 ubiquitin specific peptidase 37 (Usp37) 抗体 4932415L06Rik 抗体 C330008N13Rik 抗体 wu:fi15b04 抗体 wu:fi38d03 抗体 zgc:152882 抗体 zgc:153999 抗体