USP2 抗体
(Ubiquitin Specific Peptidase 2 (USP2))
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
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64 results :
USP2
适用: 人
WB, IHC (p)
宿主: 兔
Polyclonal
RB4417
unconjugated
12 references
USP2
适用: 人, 大鼠
WB, IHC (p)
宿主: 兔
Polyclonal
RB4202
unconjugated
4 references
USP2
适用: 人, Green Monkey
WB
宿主: 小鼠
Monoclonal
1738CT331-50-87
unconjugated
1 image
USP2
适用: 人, 犬, 马, 兔, 猴
WB, IHC, IHC (p)
宿主: 兔
Polyclonal
unconjugated
1 image
USP2
适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠, Pig
WB
宿主: 兔
Polyclonal
unconjugated
USP2
适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠
WB, IHC
宿主: 兔
Polyclonal
unconjugated
Latest Publications for our USP2 抗体
: "Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells." in: Mediators of inflammation, Vol. 2017, pp. 6909415, (2018) (PubMed).: "Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus." in: PLoS pathogens, Vol. 12, Issue 7, pp. e1005764, (2017) (PubMed).
: "Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models." in: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24628-24640, (2017) (PubMed).
: "Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas." in: Journal of the neurological sciences, Vol. 363, pp. 249-52, (2016) (PubMed).
: "Ubiquitin-specific protease 2b negatively regulates IFN-? production and antiviral activity by targeting TANK-binding kinase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 5, pp. 2230-7, (2014) (PubMed).
: "Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 12, pp. 4940-53, (2013) (PubMed).
: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).
: "Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 26, Issue 12, pp. 2923-34, (2011) (PubMed).
: "Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility." in: Biology of reproduction, Vol. 85, Issue 3, pp. 594-604, (2011) (PubMed).
: "Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2." in: American journal of physiology. Renal physiology, Vol. 301, Issue 1, pp. F189-96, (2011) (PubMed).
Aliases for USP2 抗体
ubiquitin specific peptidase 2 (USP2) 抗体ubiquitin specific peptidase 2 (Usp2) 抗体
ubiquitin specific peptidase 2a (usp2a) 抗体
B930035K21Rik 抗体
UBP-t 抗体
UBP41 抗体
Ubp41 抗体
UBP46 抗体
ubp52 抗体
ubp66 抗体
USP9 抗体
zgc:92134 抗体
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