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UGT1A3 产品

(UDP Glucuronosyltransferase 1 Family, Polypeptide A3 (UGT1A3))

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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.

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Latest Publications for our UGT1A3 Products

Kalthoff, Ehmer, Freiberg, Manns, Strassburg: "Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach." in: Gastroenterology, Vol. 139, Issue 5, pp. 1699-710, 1710.e1-2, (2010) (PubMed).

Synonyms and alternative names related to UGT1A3

UDP glucuronosyltransferase 1 family, polypeptide A3 (UGT1A3), UDP-glucuronosyltransferase 1-10 (LOC100511841), UDP glucuronosyltransferase family 1 member A3 (UGT1A3), UDP glycosyltransferase 1 family, polypeptide A3 (Ugt1a3), DKFZP469K1510, UDPGT, UDPGT 1-3, UGT-1C, Ugt1, UGT1-03, UGT1.3, Ugt1a4, UGT1C

Protein level used designations for UGT1A3

  • UDP-glucuronosyltransferase 1-3
  • UDP glucuronosyltransferase 1 family, polypeptide A3
  • UDP-glucuronosyltransferase 1-3-like
  • UDP-glucuronosyltransferase 1A3
  • UDP glycosyltransferase 1 family, polypeptide A3
  • UDP-glucuronosyltransferase 1-C
  • UGT1*3
  • B3
  • UDP glycosyltransferase 1 family polypeptide A4
  • UDPGT
  • UGT1-03
  • UGT1.3
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