UGT1A1 产品
(UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1))
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This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. [provided by RefSeq, Jul 2008].
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Featured UGT1A1 Categories
UGT1A1 抗体
High quality antibodies with extensive validation data.
UGT1A1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
UGT1A1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended UGT1A1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (6)
Cat. No.
ABIN6149895
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IF
Validations
- (4)
Cat. No.
ABIN7262012
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (5)
Cat. No.
ABIN5693290
Quantity
100 μg
Datasheet
Datasheet
Recommended UGT1A1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6960358
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6975305
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6960359
Quantity
96 tests
Datasheet
Datasheet
Recommended UGT1A1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324569
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3113166
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7408798
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our UGT1A1 Products
: "A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin." in: Journal of medicinal chemistry, Vol. 60, Issue 23, pp. 9664-9675, (2017) (PubMed).: "Phenethyl isothiocyanate and indole-3-carbinol from cruciferous vegetables, but not furanocoumarins from apiaceous vegetables, reduced PhIP-induced DNA adducts in Wistar rats." in: Molecular nutrition & food research, Vol. 60, Issue 9, pp. 1956-66, (2016) (PubMed).
: "Apiaceous vegetable consumption decreases PhIP-induced DNA adducts and increases methylated PhIP metabolites in the urine metabolome in rats." in: The Journal of nutrition, Vol. 145, Issue 3, pp. 442-51, (2015) (PubMed).
: "Fenofibrate pre-treatment suppressed inflammation by activating phosphoinositide 3 kinase/protein kinase B (PI3K/Akt) signaling in renal ischemia-reperfusion injury." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 35, Issue 1, pp. 58-63, (2015) (PubMed).
: "Danning tablets attenuates ?-naphthylisothiocyanate-induced cholestasis by modulating the expression of transporters and metabolic enzymes." in: BMC complementary and alternative medicine, Vol. 14, pp. 249, (2014) (PubMed).
Synonyms and alternative names related to UGT1A1
UDP glucuronosyltransferase family 1 member A1 (UGT1A1), UDP glucuronosyltransferase 1 family, polypeptide A1 (Ugt1a1), UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1), UDP-glucuronosyltransferase 1-1 (LOC100065342), UDP-glucuronosyltransferase (LOC100125517), UDP-glucuronosyltransferase 1-1 (LOC100229734), UDP-glucuronosyltransferase 1-6 (LOC100405984), UDP-glucuronosyltransferase 1-1 (LOC100511479), UDP glucuronosyltransferase family 1 member A1 (Ugt1a1), UDP glucuronosyltransferase 1 family polypeptide a1 (ugt1a1), BILIQTL1, GNT1, Gnt1, HUG-BR1, UDPGT, Udpgt, Udpgt-1a, UDPGT 1-1, UGT1, Ugt1, UGT1A, UGT1A01, UgtBr1, zgc:123097Protein level used designations for UGT1A1
- UDP glycosyltransferase 1 family, polypeptide A1
- UDP-glucuronosyltransferase 1-1
- UDP-glucuronosyltransferase 1-A
- UDP-glucuronosyltransferase 1A1
- UGT-1A
- UGT1*1
- UGT1-01
- UGT1.1
- bilirubin UDP-glucuronosyltransferase 1-1
- bilirubin UDP-glucuronosyltransferase isozyme 1
- bilirubin-specific UDPGT isozyme 1
- UDP-glucuronosyltransferase 1 family, member 1
- UDP-glucuronosyltransferase 1 family, polypeptide A1
- UDPGT
- UDP glucuronosyltransferase 1 family, polypeptide A1
- uridine diphosphate glucuronosyltransferase 1A1
- UDP-glucuronosyltransferase UGT1A01
- UDP glucuronosyltransferase 1 family polypeptide A1
- UDP glycosyl transferase 1A1
- UDP-glucuronosyltransferase 1-1-like
- B1
- UDP-glucuronosyltransferase 1 family member 1
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