ube3a 抗体
(Ubiquitin Protein Ligase E3A (ube3a))
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].
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Latest Publications for our ube3a 抗体
: "Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides." in: PLoS ONE, Vol. 11, Issue 8, pp. e0160159, (2017) (PubMed).
: "A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging." in: Neurobiology of learning and memory, Vol. 115, pp. 58-67, (2014) (PubMed).
: "E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis." in: Blood, Vol. 120, Issue 4, pp. 822-32, (2012) (PubMed).
: "Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a." in: Human molecular genetics, Vol. 21, Issue 13, pp. 3001-12, (2012) (PubMed).
: "Spatial and temporal silencing of the human maternal UBE3A gene." in: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, Vol. 16, Issue 6, pp. 587-91, (2012) (PubMed).
: "Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome." in: PLoS ONE, Vol. 6, Issue 12, pp. e27221, (2011) (PubMed).
: "Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 12, pp. 5611-6, (2010) (PubMed).
: "Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 11, pp. 2099-113, (2010) (PubMed).
: "E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation." in: Journal of virology, Vol. 82, Issue 21, pp. 10408-17, (2008) (PubMed).
: "Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status." in: Molecular cancer therapeutics, Vol. 6, Issue 9, pp. 2487-95, (2007) (PubMed).
: "A fine balance: Regulation of hippocampal Arc/Arg3.1 transcription, translation and degradation in a rat model of normal cognitive aging." in: Neurobiology of learning and memory, Vol. 115, pp. 58-67, (2014) (PubMed).
: "E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis." in: Blood, Vol. 120, Issue 4, pp. 822-32, (2012) (PubMed).
: "Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a." in: Human molecular genetics, Vol. 21, Issue 13, pp. 3001-12, (2012) (PubMed).
: "Spatial and temporal silencing of the human maternal UBE3A gene." in: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, Vol. 16, Issue 6, pp. 587-91, (2012) (PubMed).
: "Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome." in: PLoS ONE, Vol. 6, Issue 12, pp. e27221, (2011) (PubMed).
: "Genomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 12, pp. 5611-6, (2010) (PubMed).
: "Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development." in: Molecular endocrinology (Baltimore, Md.), Vol. 24, Issue 11, pp. 2099-113, (2010) (PubMed).
: "E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation." in: Journal of virology, Vol. 82, Issue 21, pp. 10408-17, (2008) (PubMed).
: "Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status." in: Molecular cancer therapeutics, Vol. 6, Issue 9, pp. 2487-95, (2007) (PubMed).
Aliases for ube3a 抗体
ubiquitin protein ligase E3A (UBE3A) 抗体ubiquitin-protein ligase E3A (ube3a) 抗体
ubiquitin-protein ligase E3A (LOC100194730) 抗体
ubiquitin protein ligase E3A (Ube3a) 抗体
ubiquitin protein ligase E3A (ube3a) 抗体
Ubiquitin protein ligase E3A (Ube3a) 抗体
ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog (ube3a.S) 抗体
ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (ube3a) 抗体
ubiquitin protein ligase E3A (Eint_040430) 抗体
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