This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008].
Carpino, Turner, Mekala, Takahashi, Zang, Geiger, Doherty, Ihle: "Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." in: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).
Kowanetz, Crosetto, Haglund, Schmidt, Heldin, Dikic: "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32786-95, (2004) (PubMed).
Carpino, Kobayashi, Zang, Takahashi, Jou, Feng, Nakajima, Ihle: "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7491-500, (2002) (PubMed).
Aliases for UBASH3B 抗体
ubiquitin associated and SH3 domain containing B (UBASH3B) 抗体 ubiquitin associated and SH3 domain containing, B (Ubash3b) 抗体 2810457I06Rik 抗体 BB125008 抗体 p70 抗体 RGD1310357 抗体 STS-1 抗体 Sts-1 抗体 STS1 抗体 TULA-2 抗体