This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Stadler, Fagerberg, Sivertsson, Oksvold, Zwahlen, Hallström, Lundberg, Uhlén: "RNA- and antibody-based profiling of the human proteome with focus on chromosome 19." in: Journal of proteome research, Vol. 13, Issue 4, pp. 2019-27, (2014) (PubMed).
Wang, Wilson-Berry, Schedl, Hansen: "TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 241, Issue 3, pp. 505-21, (2012) (PubMed).
Aliases for U2AF1 抗体
U2 small nuclear RNA auxiliary factor 1 (U2AF1) 抗体 CCHC-type zinc finger-containing protein (u2af1) 抗体 U2 small nuclear RNA auxiliary factor 1 (u2af1) 抗体 splicing factor U2AF 35 kDa subunit (LOC737227) 抗体 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 (U2af1) 抗体 U2 small nuclear RNA auxiliary factor 1 S homeolog (u2af1.S) 抗体 U2 small nuclear RNA auxiliary factor 1 (U2af1) 抗体 35kDa 抗体 2010107D16Rik 抗体 CHUNP6860 抗体 DDBDRAFT_0218665 抗体 DDBDRAFT_0233354 抗体 DDB_0218665 抗体 DDB_0233354 抗体 FP793 抗体 RN 抗体 RNU2AF1 抗体 U2AF35 抗体 U2AFBP 抗体 zgc:111896 抗体