This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010].
Sullivan, Huminiecki, Moore, Boyle, Poulsom, Creamer, Barker, Bicknell: "EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 47079-88, (2003) (PubMed).